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Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression

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Book cover Reviews of Physiology, Biochemistry and Pharmacology, Volume 135

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 135))

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Abbreviations

ANP:

atrial natriuretic peptide

BHK:

baby hamster kidney cells

BNP:

brain natriuretic peptide

CFTR:

cystic fibrosis transmembrane conductance regulator

cAMP-PK:

cAMP-dependent protein kinase

cGMP-PK:

cGMP-dependent protein kinase

CNP:

natriuretic peptide type C

EC:

endothelial cell

EDRF:

endothelium-derived relaxing factor

GC:

guanylyl cyclase

GnRH:

gonadotropin releasing hormone

MKP-1:

mitogen-activated protein kinase phosphatase

MLC:

myosin light chain

MLCK:

myosin light chain kinase

NLS:

nuclear localization signal

NO:

nitric oxide

NOS:

nitric oxide synthase

HUVEC:

human umbilical vein endothelial cell

8-Br-cGMP:

8-bromo-cGMP

PDGF:

platelet-derived growth factor

SHR:

spontaneously hypertensive rats

SMC:

smooth muscle cell

SNAP:

S-nitrosopenicillamine

SNP:

sodium nitroprusside

TGFβ1:

tumor growth factor beta1

TNF:

tumor necrosis factor

VASP:

vasodilator-stimulated phosphoprotein

VEGF:

vascular endothelial growth factor

References

  • Angel P, Karin M (1991) The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim Biophys Acta 1072:129–157

    Google Scholar 

  • Bassenge E (1994) Coronary vasomotor responses: role of endothelium and nitrovasodilators. Cardiovasc Drugs Ther 8:601–610

    Google Scholar 

  • Belsham DD, Wetsel WC, Mellon PL (1996) NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. EMBO J 15:538–547

    Google Scholar 

  • Bischoff J (1997) Cell adhesion and angiogenesis. J Clin Invest 99:373–376

    Google Scholar 

  • Bloch W, Forsberg E, Lentini S, Brakebusch C, Martin K, Krell HW, Weidle UH, Addicks K, Fassler R (1997) Beta 1 integrin is essential for teratoma growth and angiogenesis. J Cell Biol 139:265–278

    Google Scholar 

  • Boerth NJ, Dey NB, Cornwell TL, Lincoln TM (1997) Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype. J Vasc Res 34:245–259

    Google Scholar 

  • Bowler C, Neuhaus G, Yamagata H, Chua NH (1994) Cyclic GMP and calcium mediate phytochrome phototransduction. Cell 77:73–81

    Google Scholar 

  • Brooks PC, Clark RA, Cheresh DA (1994) Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264:569–571

    Google Scholar 

  • Burridge K, Chrzanowska-Wodnicka M, Zhong C (1997) Focal adhesion assembly. Trends Cell Biol 7:342–347

    Google Scholar 

  • Butt E, Geiger J, Jarchau T, Lohmann SM, Walter U (1993) The cGMP-dependent protein kinase — gene, protein, and function. Neurochem Res 18:27–42

    Google Scholar 

  • Butt E, Eigenthaler M, Genieser HG (1994a) Rp-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor. Eur J Pharmacol 269:265–268

    Google Scholar 

  • Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J, Walter U (1994b) cAMP-and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion protein VASP in vitro and in intact human platelets. J Biol Chem 269:14509–14517

    Google Scholar 

  • Cao L, Wu J, Gardner DG (1995) Atrial natriuretic peptide suppresses the transcription of its guanylyl cyclase-linked receptor. J Biol Chem 270:24891–24897

    Google Scholar 

  • Chen L, Daum G, Forough R, Clowes M, Walter U, Clowes AW (1998) Overexpression of human endothelial nitric oxide synthase in rat vascular smooth muscle cells and in balloon-injured carotid artery. Circ Res 82:862–870

    Google Scholar 

  • Chin K, Kurashima Y, Ogura T, Tajiri H, Yoshida S, Esumi H (1997) Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells. Oncogene 15:437–442

    Google Scholar 

  • Chu DM, Corbin JD, Grimes KA, Francis SH (1997) Activation by cyclic GMP binding causes an apparent conformational change in cGMP-dependent protein kinase. J Biol Chem 272:31922–31928

    Google Scholar 

  • Corbin JD, Lincoln TM (1978) Comparison of cAMP-and cGMP-dependent protein kinases. Adv Cyclic Nucleotide Res 9:159–170

    Google Scholar 

  • Cordelier P, Esteve JP, Bousquet C, Delesque N, O'Carroll AM, Schally AV, Vaysse N, Susini C, Buscail L (1997) Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5. Proc Natl Acad Sci USA 94:9343–9348

    Google Scholar 

  • Davenpeck KL, Gauthier TW, Lefer AM (1994) Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. Gastroenterology 107:1050–1058

    Google Scholar 

  • De Caterina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone MAJ, Shin WS, Liao JK (1995) Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 96:60–68

    Google Scholar 

  • de Groot RP, Auwerx J, Karperien M, Staels B, Kruijer W (1991) Activation of junB by PKC and PKA signal transduction through a novel cis-acting element. Nucleic Acids Res 19:775–781

    Google Scholar 

  • DeJonge HR (1981) Cyclic GMP-dependent protein kinase in intestinal brushborders. Adv Cyclic Nucleotide Res 14:315–333

    Google Scholar 

  • Dey NB, Boerth NJ, Murphy-Ullrich JE, Chang PL, Prince CW, Lincoln TM (1998) Cyclic GMP-dependent protein kinase inhibits osteopontin and thrombospondin production in rat aortic smooth muscle cells. Circ Res 82:139–146

    Google Scholar 

  • Dhaunsi GS, Hassid A (1996) Atrial and C-type natriuretic peptides amplify growth factor activity in primary aortic smooth muscle cells. Cardiovasc Res 31:37–47

    Google Scholar 

  • Draijer R, Vaandrager AB, Nolte C, De Jonge HR, Walter U, van Hinsbergh VW (1995) Expression of cGMP-dependent protein kinase I and phosphorylation of its substrate, vasodilator-stimulated phosphoprotein, in human endothelial cells of different origin. Circ Res 77:897–905

    Google Scholar 

  • Dubey RK, Jackson EK, Luscher TF (1995) Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. Role of cyclic-nucleotides and angiotensin 1 receptors. J Clin Invest 96:141–149

    Google Scholar 

  • Ecker T, Gobel C, Hullin R, Rettig R, Seitz G, Hofmann F (1989) Decreased cardiac concentration of cGMP kinase in hypertensive animals. An index for cardiac vascularization? Circ Res 65:1361–1369

    Google Scholar 

  • Eigenthaler M, Nolte C, Halbrugge M, Walter U (1992) Concentration and regulation of cyclic nucleotides, cyclic-nucleotide-dependent protein kinases and one of their major substrates in human platelets. Estimating the rate of cAMP-regulated and cGMP-regulated protein phosphorylation in intact cells. Eur J Biochem 205:471–481

    Google Scholar 

  • Eigenthaler M, Ullrich H, Geiger J, Horstrup K, Hönig-Liedl P, Wiebecke D, Walter U (1993) Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase deficient human platelets of chronic myelocytic leukemia. J Biol Chem 268:13526–13531

    Google Scholar 

  • Eigenthaler M, Shattil SJ (1996) Integrin signaling and the platelet cytoskeleton. Current Topics in Membranes 43:265–291

    Google Scholar 

  • Elferink JGR and de Koster BM (1993) The effect of cyclic GMP and cyclic AMP on migration by electroporated human neutrophils. Eur J Pharmacol 246:157–161

    Google Scholar 

  • Elferink JGR, VanUffelen BE (1996) The role of cyclic nucleotides in neutrophil migration. Gen Pharmacol 27:387–393

    Google Scholar 

  • Filippov G, Bloch DB, Bloch KD (1997) Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells. J Clin Invest 100:942–948

    Google Scholar 

  • Fisch TM, Prywes R, Simon MC, Roeder RG (1989) Multiple sequence elements in the c-fos promoter mediate induction by cAMP. Genes Dev 3:198–211

    Google Scholar 

  • Francis SH, Corbin JD (1994) Structure and function of cyclic nucleotide-dependent protein kinases. Annu Rev Physiol 56:237–272

    Google Scholar 

  • French PJ, Bijman J, Edixhoven M, Vaandrager AB, Scholte BJ, Lohmann SM, Nairn AC, DeJonge HR (1995) Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channel by cGMP-dependent protein kinase II. J Biol Chem 270:26626–26631

    Google Scholar 

  • Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA (1995) Definition of two angiogenic pathways by distinct alpha v integrins. Science 270:1500–1502

    Google Scholar 

  • Gambaryan S, Häusler C, Markert T, Pöhler D, Jarchau T, Walter U, Haase W, Kurtz A, Lohmann SM (1996) Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression. J Clin Invest 98:662–670

    Google Scholar 

  • Gambaryan S, Wagner C, Smolenski A, Walter U, Poller W, Haase W, Kurtz A, Lohmann SM (1998) Endogenous or overexpressed cGMP-dependent protein kinase inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells. Proc Natl Acad Sci USA 95:9003–9008

    Google Scholar 

  • Garg UC, Hassid A (1989) Nitric oxide-generating vasodilators and 8-Bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83:1774–1777

    Google Scholar 

  • Geiger J, Nolte C, Butt E, Sage SO, Walter U (1992) Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets. Proc Natl Acad Sci USA 89:1031–1035

    Google Scholar 

  • Geiger J, Nolte C, Walter U (1994) Regulation of calcium mobilization and calcium entry in human platelets by cyclic nucleotide-elevating and endothelium-derived factors. Am J Physiol 267:C236–C244

    Google Scholar 

  • Gill GN, Holdy KE, Walton GM, Kanstein CB (1976) Purification and characterization of 3′,5′-cyclic GMP-dependent protein kinase. Proc Natl Acad Sci USA 73:3918–3922

    Google Scholar 

  • Glass DB, Cheng HC, Kemp BE, Walsh DA (1986) Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein. J Biol Chem 261:12166–12171

    Google Scholar 

  • Gong JH, Renz H, Sprenger H, Nain M, Gemsa D (1990) Enhancement of tumor necrosis factor-alpha gene expression by low doses of prostaglandin E2 and cyclic GMP. Immunobiology 182:44–55

    Google Scholar 

  • Gorlich D, Mattaj IW (1996) Nucleocytoplasmic transport. Science 271:1513–1518

    Google Scholar 

  • Gudi T, Huvar I, Meinecke M, Lohmann SM, Boss GR, Pilz RB (1996) Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter. J Biol Chem 271:4597–4600

    Google Scholar 

  • Gudi T, Lohmann SM, Pilz RB (1997) Regulation of gene expression by cyclic GMP-dependent protein kinase requires nuclear translocation of the kinase:identification of a nuclear localization signal. Mol Cell Biol 17:5244–5254

    Google Scholar 

  • Haby C, Lisovoski F, Aunis D, Zwiller J (1994) Stimulation of the cyclic GMP pathway by NO induces expression of the immediate early genes c-fos and junB in PC12 cells. J Neurochem 62:496–501

    Google Scholar 

  • Hagiwara M, Brindle P, Harootunian A, Armstrong R, Rivier J, Vale W, Tsien R, Montminy MR (1993) Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol Cell Biol 13:4852–4859

    Google Scholar 

  • Hasegawa T, Takagi S, Nishimaki K, Morita K, Nakajima S (1992) Impairment of L-arginine metabolism in spontaneously hypertensive rats. Biochem Int 26:653–658

    Google Scholar 

  • Hofmann F, Dostmann W, Keilbach A, Landgraf W, Ruth P (1992) Structure and physiological role of cGMP-dependent protein kinase. Biochim Biophys Acta 1135:51–60

    Google Scholar 

  • Horstrup K, Jablonka B, Honig-Liedl P, Just M, Kochsiek K, Walter U (1994) Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition. Eur J Biochem 225:21–27

    Google Scholar 

  • Ignarro L, Murad F (1995) Nitric oxide. Biochemistry, molecular biology and therapeutic implications. Academic Press, San Diego

    Google Scholar 

  • Ikeda M, Kohno M, Takeda T (1995) Inhibition by cardiac natriuretic peptides of rat vascular endothelial cell migration. Hypertension 26:401–405

    Google Scholar 

  • Inoue A, Hiruma Y, Hirose S, Yamaguchi A, Hagiwara H (1995) Reciprocal regulation by cyclic nucleotides of the differentiation of rat osteoblast-like cells and mineralization of nodules. Biochem Biophys Res Commun 215:1104–1110

    Google Scholar 

  • Inoue A, Hiruma Y, Hirose S, Yamaguchi A, Furuya M, Tanaka S, Hagiwara H (1996) Stimulation by C-type natriuretic peptide of the differentiation of clonal osteoblastic MC3T3-E1 cells. Biochem Biophys Res Commun 221:703–707

    Google Scholar 

  • Itoh H, Pratt RE, Dzau VJ (1990) Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells. J Clin Invest 86:1690–1697

    Google Scholar 

  • Itoh H, Pratt RE, Ohno M, Dzau VJ (1992) Atrial natriuretic polypeptide as a novel antigrowth factor of endothelial cells. Hypertension 19:758–761

    Google Scholar 

  • Jarchau T, Hausler C, Markert T, Pohler D, Vanderkerckhove J, De Jonge HR, Lohmann SM, Walter U (1994) Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II. Proc Natl Acad Sci USA 91:9426–9430

    Google Scholar 

  • Johnston HM, Morris BJ (1994) NMDA and nitric oxide increase microtubule-associated protein 2 gene expression in hippocampal granule cells. J Neurochem 63:379–382

    Google Scholar 

  • Kalderon D, Rubin G M (1989) cGMP-dependent protein kinase genes in Drosophila. J Biol Chem 264:10738–10748

    Google Scholar 

  • Kaupp UB (1995) Family of cyclic nucleotide gated ion channels. Curr Opin Neurobiol 5:434–442

    Google Scholar 

  • Kawada N, Kuroki T, Uoya M, Inoue M, Kobayashi K (1996) Smooth muscle alpha-actin expression in rat hepatic stellate cell is regulated by nitric oxide and cGMP production. Biochem Biophys Res Commun 229:238–242

    Google Scholar 

  • Kemp BE, Cheng H-C, Walsh DA (1988) Peptide inhibitors of cAMP-dependent protein kinases. Methods Enzymol 159:173–183

    Google Scholar 

  • Kim YM, Talanian RV, Billiar TR (1997) Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J Biol Chem 272:31138–31148

    Google Scholar 

  • Koesling D, Bohme E, Schultz G (1991) Guanylyl cyclases, a growing family of signal-transducing enzymes. FASEB J 5:2785–2791

    Google Scholar 

  • Kohno M, Yokokawa K, Yasunari K, Kano H, Minami M, Ueda M, Yoshikawa J (1997) Effect of natriuretic peptide family on the oxidized LDL-induced migration of human coronary artery smooth muscle cells. Circ Res 81:585–590

    Google Scholar 

  • Kuo JF, Greengard P (1970) Cyclic nucleotide-dependent protein kinase VI. Isolation and partial purification of a protein kinase activated by guanosine 3′,5′-monophosphate. J Biol Chem 245:2493–2498

    Google Scholar 

  • Kuo JF, Davis CW, Tse J (1976) Depressed cardiac cyclic GMP-dependent protein kinase in spontaneously hypertensive rats and its further depression by guanethidine. Nature 261:335–336

    Google Scholar 

  • Kurose I, Kubes P, Wolf R, Anderson DC, Paulson J, Miyasaka M, Granger DN (1993) Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage. Circ Res 73:164–171

    Google Scholar 

  • Lau YT, Ma WC (1996) Nitric oxide inhibits migration of cultured endothelial cells. Biochem Biophys Res Commun 221:670–674

    Google Scholar 

  • Lee MR, Li L, Kitazawa T (1997) Cyclic GMP causes Ca2+ desensitization in vascular smooth muscle by activating the myosin light chain phosphatase. J Biol Chem 272:5063–5068

    Google Scholar 

  • Lincoln TM, Dills WL, Corbin JD (1977) Purification and subunit composition of guanosine 3′:5′-monophosphate-dependent protein kinase from bovine lung. J Biol Chem 252:4269–4275

    Google Scholar 

  • Lincoln TM, Komalavilas P, Boerth NJ, MacMillan-Crow LA, Cornwell TL (1995a) cGMP signaling through cAMP-and cGMP-dependent protein kinases. Adv Pharmacol 34:305–322

    Google Scholar 

  • Lincoln TM (1995b) Nitric oxide in the nervous system. Academic Press, San Diego 51 pp

    Google Scholar 

  • Lohmann SM, Vaandrager AB, Smolenski A, Walter U, DeJonge HR (1997) Distinct and specific functions of cGMP-dependent protein kinases. TIBS 22:307–312

    Google Scholar 

  • Loweth AC, Williams GT, Scarpello JH, Morgan NG (1997) Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15. FEBS Lett 400:285–288

    Google Scholar 

  • Markert T, Krenn V, Leebmann J, Walter U (1996) High expression of the focal adhesion-and microfilament-associated protein VASP in vascular smooth muscle and endothelial cells of the intact human vessel wall. Basic Res Cardiol 91:337–343

    Google Scholar 

  • Matsuoka H, Nakata M, Kohno K, Koga Y, Nomura G, Toshima H, Imaizumi T (1996) Chronic L-arginine administration attenuates cardiac hypertrophy in spontaneously hypertensive rats. Hypertension 27:14–18

    Google Scholar 

  • McEver RP, Cummings RD (1997) Perspectives series:cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest 100:485–491

    Google Scholar 

  • Mecham RP, Levy BD, Morris SL, Madaras JG, Wrenn DS (1985) Increased cyclic GMP levels lead to a stimulation of elastin production in ligament fibroblasts that is reversed by cyclic AMP. J Biol Chem 260:3255–3258

    Google Scholar 

  • Mönks D, Lange V, Silber RE, Markert T, Walter U, Nehls V (1998) Expression of cGMP-dependent protein kinase I and its substrate VASP in neointimal cells of the injured rat carotid artery. Eur J Clin Invest, 28:416–423

    Google Scholar 

  • Morita T, Mitsialis SA, Koike H, Liu Y, Kourembanas S (1997) Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells. J Biol Chem 272:32804–32809

    Google Scholar 

  • Murphy-Ullrich JE, Pallero MA, Boerth N, Greenwood JA, Lincoln TM, Cornwell TL (1996) Cyclic GMP-dependent protein kinase is required for thrombospondin and tenascin mediated focal adhesion disassembly. J Cell Sci 109:2499–2508

    Google Scholar 

  • Niu XF, Smith CW, Kubes P (1994) Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils. Circ Res 74:1133–1140

    Google Scholar 

  • Niu XF, Ibbotson G, Kubes P (1996) A balance between nitric oxide and oxidants regulates mast cell-dependent neutrophil-endothelial cell interactions. Circ Res 79:992–999

    Google Scholar 

  • Nolte C, Eigenthaler M, Schanzenbächer P, Walter U (1991) Endothelial cell-dependent phosphorylation of a platelet protein mediated by cAMP-and cGMP-elevating factors. J Biol Chem 266:14808–14812

    Google Scholar 

  • Orstavik S, Natarajan V, Tasken K, Jahnsen T, Sandberg M (1997) Characterization of the human gene coding for the type I alpha and type I beta cGMP-dependent protein kinase. Genomics 42:311–318

    Google Scholar 

  • Osborne KA, Robichon A, Burgess E, Butland S, Shaw RA, Coulthard A, Pereira HS, Greenspan RJ, Sokolowski MB (1996) Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila. Science 277:834–836

    Google Scholar 

  • Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, Garcia-Cardena G, Madri JA, Sessa WC (1997a) Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. Am J Pathol 150:1835–1844

    Google Scholar 

  • Papapetropoulos A, Garcia-Cardena G, Madri JA, Sessa WC (1997b) Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 100:3131–3139

    Google Scholar 

  • Parenti A, Morbidelli L, Cui XL, Douglas JG, Hood JD, Granger HJ, Ledda F, Ziche M (1998) Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase 1/2 activation in postcapillary endothelium. J Biol Chem 273:4220–4226

    Google Scholar 

  • Peng HB, Libby P, Liao JK (1995) Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J Biol Chem 270:14214–14219

    Google Scholar 

  • Perez-Albuerne ED, Schatteman G, Sanders LK, Nathans D (1993) Transcriptional regulatory elements downstream of the JunB gene. Proc Natl Acad Sci USA 90:11960–11964

    Google Scholar 

  • Peunova N, Enikolopov G (1993) Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells. Nature 364:450–453

    Google Scholar 

  • Pfeifer A, Nurnberg B, Kamm S, Uhde M, Schultz G, Ruth P, Hofmann F (1995) Cyclic GMP-dependent protein kinase blocks pertussis-toxin.sensitive hormone receptor signaling pathways in Chinese hamster ovary cells. J Biol Chem 270:9052–9059

    Google Scholar 

  • Pfeifer A, Aszodi A, Seidler U, Ruth P, Hofmann F, Fässler R (1996) Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science 274:2082–2086

    Google Scholar 

  • Pfeifer A, Klatt P, Massberg S, Ny L, Sausbier M, Hirneiss C, Wang G-X, Korth M, Aszodi A, Andersson K-E, Krombach F, Mayerhofer A, Ruth P, Fässler R, Hofmann F (1998) Defective smooth muscle regulation in cGMP kinase I-deficient mice. EMBO J 17:3045–3051

    Google Scholar 

  • Pilz RB, Berjis M, Idriss SD, Scheele JS, Suhasini M, Gao L, Scheffler IE, Boss GR (1994) Isolation and characterization of HL-60 cells resistant to nitroprusside-induced differentiation. J Biol Chem 269:32155–32161

    Google Scholar 

  • Pilz RB, Suhasini M, Idriss S, Meinkoth JL, Boss GR (1995) Nitric oxide and cGMP analogs activate transcription from AP-1-responsive promoters in mammalian cells. FASEB J 9:552–558

    Google Scholar 

  • Pollman MJ, Yamada T, Horiuchi M, Gibbons GH (1996) Vasoactive substances regulate vascular smooth muscle cell apoptosis. Countervailing influences of nitric oxide and angiotensin II. Circ Res 79:748–756

    Google Scholar 

  • Pryzwansky KB, Wyatt TA, Nichols H, Lincoln TM (1990) Compartmentalization of cyclic GMP-dependent protein kinase in formyl-peptide stimulated neutrophils. Blood 76:612–618

    Google Scholar 

  • Pryzwansky KB, Kidao S, Wyatt TA, Reed W, Lincoln TM (1995a) Localization of cyclic GMP-dependent protein kinase in human mononuclear phagocytes. J Leukoc Biol 57:670–678

    Google Scholar 

  • Pryzwansky KB, Wyatt TA, Lincoln TM (1995b) Cyclic guanosine monophosphate-dependent protein kinase is targeted to intermediate filaments and phosphorylates vimentin in A23187-stimulated human neutrophils. Blood 85:222–230

    Google Scholar 

  • Radomski MW, Palmer RM, Moncada S (1987) The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 148:1482–1489

    Google Scholar 

  • Reinhard M, Jarchau T, Walter U (1998) VASP. In: Guidebook to the cytoskeletal and motor proteins (Eds. Kreis T, Vale R), Oxford University Press, in press

    Google Scholar 

  • Rhoades KL, Golub SH, Economou JS (1992) The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines. J Biol Chem 267:22102–22107

    Google Scholar 

  • Ruth P, Wang GX, Boekhoff I, May B, Pfeifer A, Penner R, Korth M, Breer H, Hofmann F (1993) Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-trisphosphate production. Proc Natl Acad Sci USA 90:2623–2627

    Google Scholar 

  • Rybalkin SD, Beavo J (1996) Multiplicity within cyclic nucleotide phosphodiesterases. Biochem Soc Trans 24:1005–1009

    Google Scholar 

  • Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (1989) Molecular cloning and predicted full-length amino acid sequence of the type Iß isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat. FEBS Lett 225:321–329.

    Google Scholar 

  • Sansom SC, Stockand JD, Hall D, Williams B (1997) Regulation of large calcium-activated potassium channels by protein phosphatase 2A. J Biol Chem 272:9902–9906

    Google Scholar 

  • Sarkar R, Meinberg EG, Stanley JC, Gordon D, Webb RC (1996) Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells. Circ Res 78:225–230

    Google Scholar 

  • Schmidt HHHW, Walter U (1994) NO at work. Cell 78, 919–925.

    Google Scholar 

  • Schwartz SM (1997) Smooth muscle migration in atherosclerosis and restenosis. J Clin Invest 100:S87–S89

    Google Scholar 

  • Smolenski A, Burkhardt M, Eigenthaler M, Butt E, Gambaryan S, Lohmann SM, Walter U (1998) Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn-Schmiedeberg's Arch Pharmacol 358:134–139

    Google Scholar 

  • Soff GA, Cornwell TL, Cundiff DL, Gately S, Lincoln TM (1997) Smooth muscle expression of type I cyclic GMP-dependent protein kinase is suppressed by continuous exposure to nitrovasodilators, theophylline, cyclic GMP, and cyclic AMP. J Clin Invest 100:2580–2587

    Google Scholar 

  • Stockert RJ, Ren Q (1997) Cytoplasmic protein mRNA interaction mediates cGMP-modulated translational control of the asialoglycoprotein receptor. J Biol Chem 272:9161–9165

    Google Scholar 

  • Suda M, Ogawa Y, Tanaka K, Tamura N, Yasoda A, Takigawa T, Uehira M, Nishimoto H, Itoh H, Saito Y, Shiota K, Nakao K (1998) Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide. Proc Natl Acad Sci USA 95:2337–2342

    Google Scholar 

  • Sugimoto T, Haneda M, Togawa M, Isono M, Shikano T, Araki S, Nakagawa T, Kashiwagi A, Guan KL, Kikkawa R (1996) Atrial natriuretic peptide induces the expression of MKP-1, a mitogen-activated protein kinase phosphatase, in glomerular mesangial cells. J Biol Chem 271:544–547

    Google Scholar 

  • Suhasini M, Li H, Lohmann SM, Boss GR, Pilz RB (1998) cGMP-dependent protein kinase inhibits the ras/mitogen-activated protein kinase pathway. Mol Cell Biol, in press

    Google Scholar 

  • Sundqvist T, Forslund T, Bengtsson T, Axelsson KL (1994) S-nitroso-N-acetylpenicillamine reduces leukocyte adhesion to type I collagen. Inflammation 18:625–631

    Google Scholar 

  • Takahashi M, Ikeda U, Masuyama J, Funayama H, Kano S, Shimada K (1996) Nitric oxide attenuates adhesion molecule expression in human endothelial cells. Cytokine 8:817–821

    Google Scholar 

  • Takio K, Wade RD, Smith SB, Krebs EG, Walsh KA, Titani K (1984) Guanosine cyclic 3′,5′-phosphate-dependent protein kinase, a chimeric protein homologous with two separate protein families. Biochemistry 23:4207–4218

    Google Scholar 

  • Tetsuka T, Daphna-Iken D, Miller BW, Guan Z, Baier LD, Morrison AR (1996) Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells. J Clin Invest 97:2051–2056

    Google Scholar 

  • Thiriet N, Esteve L, Aunis D, Zwiller J (1997) Immediate early gene induction by natriuretic peptides in PC12 phaeochromocytoma and C6 glioma cells. Neuroreport 8:399–402

    Google Scholar 

  • Tsao PS, Buitrago R, Chan JR, Cooke JP (1996) Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1. Circulation 94:1682–1689

    Google Scholar 

  • Uberall F, Werner-Felmayer G, Schubert C, Grunicke HH, Wachter H, Fuchs D (1994) Neopterin derivatives together with cyclic guanosine monophosphate induce c-fos gene expression. FEBS Lett 352:11–14

    Google Scholar 

  • Uhler M D (1993) Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem 268:13586–13591

    Google Scholar 

  • Vaandrager AB, DeJonge HR (1996) Signalling by cGMP-dependent protein kinases. Mol Cell Biochem 157:23–30

    Google Scholar 

  • Vaandrager AB, Tilly BC, Smolenski A, Schneider-Rasp S, Bot AGM, Edixhoven M, Scholte BJ, Jarchau T, Walter U, Lohmann SM, Poller WC, DeJonge HR (1997) cGMP-stimulation of cystic fibrosis transmembrane conductance regulator Cl− channels co-expressed with cGMP-dependent protein kinase type II but not type Iß. J Biol Chem 272:4195–4200

    Google Scholar 

  • Vaandrager AB, Smolenski A, Tilly BC, Housmuller AB, Ehlert EME, Bot AGM, Edixhoven M, Boomaars WEM, Lohmann SM, DeJonge HR (1998) Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl− channel activation. Proc Natl Acad Sci USA 95:1466–1471

    Google Scholar 

  • Vemulapalli S, Chiu PJ, Kurowski S, Brown A, Hartman BD, Leach MW (1996) In vivo inhibition of platelet adhesion by a cGMP-mediated mechanism in balloon catheter injured rat carotid artery. Pharmacology 52:235–242

    Google Scholar 

  • Venturini CM, Weston LK, Kaplan JE (1992) Platelet cGMP, but not cAMP, inhibits thrombin-induced platelet adhesion to pulmonary vascular endothelium. Am J Physiol 263:H606–H612

    Google Scholar 

  • Vo NK, Gettemy JM, Coghlan VM (1998) Identification of cGMP-dependent protein kinase anchoring proteins (GKAPs). Biochem Biophys Res Commun 246:831–835

    Google Scholar 

  • Waldmann R, Walter U (1989) Cyclic nucleotide elevating vasodilators inhibit platelet aggregation at an early step of the activation cascade. Eur J Pharmacol 159:317–320

    Google Scholar 

  • Walter U (1984) Cyclic GMP-regulated enzymes and their possible physiological functions. Adv Cycl Nucl Prot Phosphor Res 17:249–258

    Google Scholar 

  • Walter U (1989) Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system. Rev Physiol Biochem Pharmacol 113:41–88

    Google Scholar 

  • Wang GR, Zhu Y, Halushka PV, Lincoln TM, Mendelsohn ME (1998) Mechanism of platelet inhibition by nitric oxide:In vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Proc Natl Acad Sci USA 95:4888–4893

    Google Scholar 

  • Wang S, Yan L, Wesley RA, Danner RL (1997) Nitric oxide increases tumor necrosis factor production in differentiated U937 cells by decreasing cyclic AMP. J Biol Chem 272:5959–5965

    Google Scholar 

  • Wedel A, Sulski G, Ziegler-Heitbrock HW (1996) CCAAT/enhancer binding protein is involved in the expression of the tumour necrosis factor gene in human monocytes. Cytokine 8:335–341

    Google Scholar 

  • Wedel BJ, Garbers DL (1997) New insights on the functions of the guanylyl cyclase receptors. FEBS Lett 410:29–33

    Google Scholar 

  • Wernet W, Flockerzi V, Hofmann F (1989) The cDNA of the two isoforms of bovine cGMP-dependent protein kinase. FEBS Lett 251:191–196

    Google Scholar 

  • Wu CC, Ko FN, Teng CM (1997) Inhibition of platelet adhesion to collagen by cGMP-elevating agents. Biochem Biophys Res Commun 231:412–416

    Google Scholar 

  • Wu X, Haystead TAJ, Nakamoto RK, Somlyo AV, Somlyo AP (1998) Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergism with cyclic nucleotide-activated kinase. J Biol Chem 273:11362–11369

    Google Scholar 

  • Wyatt TA, Lincoln TM, Pryzwansky KB (1991) Vimentin is transiently co-localized with and phosphorylated by cyclic GMP-dependent protein kinase in formyl-peptide-stimulated neutrophils. J Biol Chem 266:21274–21280

    Google Scholar 

  • Yamada KM and Geiger B (1997) Molecular interactions in cell adhesion complexes. Curr Opin Cell Biol 9:76–85

    Google Scholar 

  • Yoshida T, Hayashi M, Monkawa T, Saruta T (1996) Regulation of obese mRNA expression by hormonal factors in primary cultures of rat adipocytes. Eur J Endocrinol 135:619–625

    Google Scholar 

  • Yu SM, Hung LM, Lin CC (1997) cGMP-elevating agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signaling pathway. Circulation 95:1269–1277

    Google Scholar 

  • Zhou XB, Ruth P, Schlossmann J, Hofmann F, Korth M (1996) Protein phosphatase 2A is essential for the activation Ca2+-activated K+ currents by cGMP-dependent protein kinase in tracheal smooth muscle and Chinese hamster ovary cells. J Biol Chem 271:19760–19767

    Google Scholar 

  • Ziche M, Morbidelli L, Choudhuri R, Zhang HT, Donnini S, Granger HJ, Bicknell R (1997) Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 99:2625–2634

    Google Scholar 

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Authors and Affiliations

  1. Institut für Klinische Biochemie und Pathobiochemie, Medizinische Universitätsklinik, Josef-Schneider-Straße 2, D-97080, Würzburg, Germany

    M. Eigenthaler, S. M. Lohmann, U. Walter & R. B. Pilz

  2. Department of Medicine, University of California, 92093-0652, San Diego, La Jolla, CA, USA

    R. B. Pilz

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  1. M. Eigenthaler
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  3. U. Walter
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Eigenthaler, M., Lohmann, S.M., Walter, U., Pilz, R.B. (1999). Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 135. Reviews of Physiology, Biochemistry and Pharmacology, vol 135. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0033673

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