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Cl− channels in smooth muscle cells

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A Publisher's Erratum to this article was published on 16 April 2014

Abstract

In smooth muscle cells (SMCs), the intracellular chloride ion (Cl−) concentration is high due to accumulation by Cl−/HCO3 − exchange and Na+–K+–Cl− cotransportation. The equilibrium potential for Cl− (E Cl) is more positive than physiological membrane potentials (E m), with Cl− efflux inducing membrane depolarization. Early studies used electrophysiology and nonspecific antagonists to study the physiological relevance of Cl− channels in SMCs. More recent reports have incorporated molecular biological approaches to identify and determine the functional significance of several different Cl− channels. Both “classic” and cGMP-dependent calcium (Ca2+)-activated (ClCa) channels and volume-sensitive Cl− channels are present, with TMEM16A/ANO1, bestrophins, and ClC-3, respectively, proposed as molecular candidates for these channels. The cystic fibrosis transmembrane conductance regulator (CFTR) has also been described in SMCs. This review will focus on discussing recent progress made in identifying each of these Cl− channels in SMCs, their physiological functions, and contribution to diseases that modify contraction, apoptosis, and cell proliferation.

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Acknowledgments

We thank M. Dennis Leo and Sarah K. Burris for reading the manuscript. This work was supported by National Institutes of Health Heart, Lung and Blood grants (HL67061, HL094378, and HL110347) awarded to Jonathan H. Jaggar.

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  1. Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

    Simon Bulley & Jonathan H. Jaggar

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Bulley, S., Jaggar, J.H. Cl− channels in smooth muscle cells. Pflugers Arch - Eur J Physiol 466, 861–872 (2014). https://doi.org/10.1007/s00424-013-1357-2

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