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Emerging roles of cytomegalovirus-encoded G protein-coupled receptors during lytic and latent infection

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Abstract

Cytomegaloviruses (CMVs) have developed multiple diverse strategies to ensure their replicative success and to evade immune recognition. Given the fact that G protein-coupled receptors (GPCRs) are key regulators of numerous cellular processes and modify a variety of signaling pathways, it is not surprising that CMVs and other herpesviruses have hijacked mammalian GPCRs during their coevolution. Human cytomegalovirus (HCMV) encodes for four viral GPCR homologues (vGPCRs), termed US27, US28, UL33, and UL78. Although HCMV-encoded GPCRs were first described in 1990, the pivotal functions of these viral receptor proteins were detected only recently. Here, we summarize seminal knowledge on the functions of herpesviral vGPCRs with a focus on novel roles of cytomegalovirus-encoded vGPCRs for viral spread and the regulation of latency.

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Acknowledgements

This work was supported by the Deutsche Forschungsgemeinschaft (STA357/7-1), the Wilhelm-Sander-Stiftung (2016.087.1) and the Kompetenznetzwerk Zytomegalie Baden-Württemberg (KSKV002).

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  1. Institute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Theresa Frank & Ina Niemann

  2. Institute for Virology, Ulm University Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany

    Anna Reichel & Thomas Stamminger

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  1. Theresa Frank
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  2. Ina Niemann
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This article is part of the Special Issue on “Immunological Imprinting during Chronic Viral Infection”.

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Frank, T., Niemann, I., Reichel, A. et al. Emerging roles of cytomegalovirus-encoded G protein-coupled receptors during lytic and latent infection. Med Microbiol Immunol 208, 447–456 (2019). https://doi.org/10.1007/s00430-019-00595-9

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