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Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemia

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Abstract

We describe a child with familial hypocalciuric hypercalcemia (FHH) in whom the hypercalcemia seemed to interfere with tissue healing after tympanoplasty. Consequently, he was placed on cinacalcet (30 mg/day), changed after 2 weeks to 60 mg/day. The treatment resulted in a decrease in serum parathyroid hormone (PTH) from 148 to 32 pg/mL (normal 7–75) and ionized calcium from 1.48 to 1.23 mmol/L (1.13–1.34), as well as successful healing of the revised surgical scar. Over the 12-month treatment period no complications were noted. We conclude that cinacalcet may be considered a new, and currently the only, tool in treating children with symptomatic FHH.

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Acknowledgements

Supported by the Sam and Helen Kaplan Research Fund in Pediatric Nephrology and the Eric McClure Research Fund in Pediatric Bone and Mineral Disorders.

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  1. Section of Pediatric Nephrology, Bone and Mineral Disorders Clinic, Children’s Mercy Hospitals and Clinics, University of Missouri at Kansas City, 2401 Gillham Road, Kansas City, MI, 64108, USA

    Uri S. Alon & René G. VanDeVoorde

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  1. Uri S. Alon
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  2. René G. VanDeVoorde
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Correspondence to Uri S. Alon.

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Alon, U.S., VanDeVoorde, R.G. Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemia. Pediatr Nephrol 25, 1747–1750 (2010). https://doi.org/10.1007/s00467-010-1547-5

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  • DOI: https://doi.org/10.1007/s00467-010-1547-5

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