Abstract
We present here a series of high-density maps of single-nucleotide polymorphisms (SNPs) detected in genes encoding three organic-anion transporters, three organic anion-transporting polypeptides, and three nicotinamide adenine dinucleotide, reduced:ubiquinone oxidoreductase flavoproteins. A total of 258 SNPs were identified among these nine genes through systematic screening of DNA from 48 Japanese individuals: 17 in 5′ flanking regions, three in 5′ untranslated regions, 13 in coding regions, 211 in introns, six in 3′ untranslated regions, and 8 in 3′ flanking regions. By comparing our data with SNPs deposited in the dbSNP database in the National Center for Biotechnology Information, we determined that 236 (91.5%) were novel. In addition, 46 genetic variations of other types were discovered within these loci. These high-resolution maps will serve as a useful resource for analyzing potential associations between variations in these nine genes and differences in human susceptibilities to common diseases or response to drug therapies.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Additional information
Received: August 15, 2001 / Accepted: August 23, 2001
Rights and permissions
About this article
Cite this article
Iida, A., Saito, S., Sekine, A. et al. Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins. J Hum Genet 46, 668–683 (2001). https://doi.org/10.1007/s100380170019
Issue Date:
DOI: https://doi.org/10.1007/s100380170019
This article is cited by
-
Has the era of individualised medicine arrived for antifungals? A review of antifungal pharmacogenomics
Bone Marrow Transplantation (2012)
-
Pharmacokinetic Impact of SLCO1A2 Polymorphisms on Imatinib Disposition in Patients With Chronic Myeloid Leukemia
Clinical Pharmacology & Therapeutics (2011)
-
Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk
Breast Cancer Research and Treatment (2011)
-
Variants in the SLCO1B3 Gene: Interethnic Distribution and Association with Paclitaxel Pharmacokinetics
Clinical Pharmacology & Therapeutics (2007)
-
Drug transporters in pharmacokinetics
Naunyn-Schmiedeberg's Archives of Pharmacology (2006)