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Calcium antagonists in myocardial ischemia/reperfusion—update 2012

Kalzium-Antagonisten bei myokardialer Ischämie und Reperfusion – Update 2012

  • Kalzium in der kardialen Pathophysiologie
  • Published:
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Summary

The present article briefly reviews the processes underlying excitation–contraction coupling in cardiomyocytes and vascular smooth muscle cells, their perturbations during reversible and irreversible myocardial ischemia and reperfusion, notably the pathogenetic role of increased intracellular calcium concentrations, and finally the beneficial effects of calcium antagonists on the impairment of coronary vasomotor tone, on cardiac contractile dysfunction and on myocardial infarction.

Zusammenfassung

Die vorliegende Übersicht charakterisiert kurz die grundlegenden Prozesse der elektromechanischen Kopplung in Kardiomyozyten und glatten Gefäßmuskelzellen, ihre Veränderungen bei reversibler und irreversibler myokardialer Ischämie und Reperfusion, insbesondere die pathogenetische Funktion der erhöhten intrazellulären Kalziumkonzentration, sowie schließlich die protektiven Wirkungen von Kalziumantagonisten auf den gestörten koronaren Vasomotorentonus, die kontraktile Dysfunktion und die myokardiale Infarktausprägung.

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  1. Gerd Heusch FRCP

    Present address: Institut für Pathophysiologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Germany

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  1. Institut für Pathophysiologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Germany

    Petra Kleinbongard PhD & Theodor Baars MD

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  1. Petra Kleinbongard PhD
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  2. Theodor Baars MD
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  3. Gerd Heusch FRCP
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Correspondence to Gerd Heusch FRCP.

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Kleinbongard, P., Baars, T. & Heusch, G. Calcium antagonists in myocardial ischemia/reperfusion—update 2012. Wien Med Wochenschr 162, 302–310 (2012). https://doi.org/10.1007/s10354-012-0113-0

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  • DOI: https://doi.org/10.1007/s10354-012-0113-0

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