Microbial models of mammalian metabolism. Aromatic hydroxylation
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2021, Enzyme and Microbial TechnologyMicrobial transformations of buagarofuran, an anti-anxietic agent
2014, TetrahedronCitation Excerpt :The metabolism study of buagarofuran revealed that various metabolites were detected when incubated with rat and human liver microsomal fractions. However, only two metabolites, 2-hydroxy- and 2-oxo-buagarofuran, were identified because of limited scale, ethnics, etc.4 As reported, microbial transformations could be used for the preparation of mammalian drug metabolites.5–7 Once identities of the microbial and mammalian drug metabolites have been established, the microbial metabolites can be prepared in sufficient quantity to be used in biological activity and toxicity tests, preparation of analytical standards, and so on.