Rat heart mitochondria release adenosine

https://doi.org/10.1016/0006-291X(83)91096-3Get rights and content

Abstract

Isolated rat heart mitochondria release adenosine under specific conditions. Lowest adenosine release occurs at 4°C while highest release occurs in the presence of pyruvate + malate or rotenone at 30°C. The release is attenuated during state 3 respiration, in the presence of atractyloside or in the presence of 1799. Oligomycin only partially decreases adenosine release. Release is unaffected by 200 μM Ca++ and is independent of oxygen concentration as low as 2 μM. The data are consistent with the hypothesis that adenosine is released from mitochondria via the adenine nucleotide transporter and the release is regulated by the intramitochondrial ATP to ADP ratio.

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