Neuromedin C: A bombesin-like peptide identified in porcine spinal cord

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Abstract

From a side fraction obtained in our previous isolation of neuromedin B from porcine spinal cord, we have purified another decapeptide that exhibits a potent stimulant effect on the smooth muscle preparation of rat uterus. By microsequencing and synthesis, the amino acid sequence of the peptide has been identified as: Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2. This peptide is found to be identical with the carboxy-terminal subsequence [18–27] of gastrin releasing peptide, and to display a potent contractile activity on rat uterus in the characteristic manner of bombesin. These facts strongly suggest that the peptide may be a neuromediator in the neural communication systems of mammals. We propose the name “neuromedin C” for this peptide, since it is closely related to “neuromedin B”, recently identified as a bombesin-like mammalian peptide.

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    Citation Excerpt :

    Ten newer neuropeptides have been discovered being endogenous ligands for orphan GPCRs [3] “Neuromedin” one such novel discovery. Neuromedin peptides are basically divided into 4 classes (1) Bombesin comprising of Neuromedin B and Neuromedin C, (2) Kanassin comprises of Neuromedin K and Neuromedin L, (3) Neurotensin comprises of Neuromedin N, (4) Neuromedin U and Neuromedin S. Isolation of the first neuromedin took place in the 1980s from porcine spinal cord which had large amount of vasoconstrictor properties which was Neuromedin U [4–9] the first neuropeptide of all, later on its different isoforms were discovered. Neuromedin U was found in brain and periphery and has many physiological aspects which include constrictive effects on the smooth muscles, control of blood pressure, pain sensations, hunger, bone metastasis and release and regulation of hormones [10–17].

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