Biochemical and Biophysical Research Communications
Characterization of neuromedin U like immunoreactivity in rat, porcine guinea-pig and human tissue extracts using a specific radioimmunoassay
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Cited by (74)
The neuromedin U system: Pharmacological implications for the treatment of obesity and binge eating behavior
2023, Pharmacological ResearchCloning and expression patterns of neuromedin U and its receptors in pigs
2017, NeuropeptidesCitation Excerpt :However, we also detected pig NMU mRNA in the stomach and the liver. This observation was different from the previous data obtained in rats and guinea pigs (Domin et al., 1986; Honzawa et al., 1990), suggesting differences in NMU expression in different species (Graham et al., 2003). RIA revealed significant NMU-LIR expression in most of the rat genitourinary tract, with the highest levels observed in the ureter, vas deferens, prostate, fallopian tubes, urethra, testis, and ovaries (Domin et al., 1986; Fujii et al., 2000).
Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U
2016, Biological PsychiatryCitation Excerpt :Together, our data demonstrate a GABAergic pathway from the DRN to the NAcSh that can be modulated through NMUR2 to regulate behavioral sensitization to cocaine. Although the specific source of NMU is unclear, the NAc expresses the highest levels of NMU peptide in the brain (11). Furthermore, microarray studies have identified NMU mRNA as a transcript in the NAc that is stimulated by methamphetamine (56).
Small lipidated anti-obesity compounds derived from neuromedin U
2015, European Journal of Medicinal ChemistryCitation Excerpt :Neuromedin U (NmU) is an endogenous peptide, highly conserved across species, that is implicated in a number of physiological processes including nociception, stress, inflammation, blood pressure, feeding, energy homeostasis, and glycemic control [6,7]. NmU is widely distributed in the body both peripherally and centrally [8–11], and its function is mediated by two G-protein coupled receptors (GPCRs): NMU1 and NMU2 [6,12–18]. NMU1 is predominantly expressed in the peripheral tissues, particularly the gastrointestinal tract, pancreas, uterus and testes [16,18], whereas NMU2 is mainly expressed in the central nervous system (CNS) with the highest levels in the hypothalamus, hippocampus, spinal cord and paraventricular nucleus [11,14,15].
Neuromedin U
2013, Handbook of Biologically Active PeptidesNeuromedins U/S
2013, Handbook of Biologically Active Peptides