Biochemical and Biophysical Research Communications
Re-examination of [3H]mepyramine binding assay for histamine H1 receptor using quinine
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Investigation on signal transduction pathways after H <inf>1</inf> receptor activated by histamine in C6 glioma cells: Involvement of phosphatidylinositol and arachidonic acid metabolisms
2012, Journal of the Chinese Medical AssociationCitation Excerpt :The C6 glioma cell line was established around 1968,1 and it has been used for physiologic and pharmacologic studies because this cell line, having a glial cell origin, contains many types of receptors such as adrenergic, serotonergic, muscarinic, adenosine 5′-triphosphate (ATP), bradykinin, and endothelin.2–4 For the histaminergic system, Peakman and Hill5 reported that histamine caused an increase in [3H] phosphatidylinositol (PI) turnover and inositol 4-phosphate (IP1) accumulation; however, an apparent lack of endogenous histamine H1 receptors in C6 cells was reported by Liu and others6 and Fujimoto and colleagues.7 Therefore, it was interesting to know if histamine-mediated signal transduction system can still be detected in this cell line or not.
Characteristics of [<sup>3</sup>H]mepyramine binding in DDT<inf>1</inf>MF-2 cells: Evidence for high affinity binding to a functional histamine H<inf>1</inf> receptor
1994, European Journal of Pharmacology: Molecular PharmacologyHigh, stable expression of the bovine histamine h<inf>1</inf>-receptor coupled to [Ca<sup>2+</sup>]<inf>i</inf> mobilization in CHO-K1 cells
1993, Biochemical and Biophysical Research CommunicationsRegulation of the cardiovascular system by histamine
2017, Handbook of Experimental PharmacologyBiological and pharmacological aspects of histamine receptors and their ligands
2011, Biomedical Aspects of Histamine: Current PerspectivesHistamine, histamine receptors, and their role in immunomodulation: An updated systematic review
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