Identification, kinetic and quantitative study of [2-14C] and [1-Me-14C]caffeine metabolites in rat's urine by chromatographic separations
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Cited by (46)
Improvement of mitochondrial NAD<sup>+</sup>/FAD<sup>+</sup>-linked state-3 respiration by caffeine attenuates quinolinic acid induced motor impairment in rats: Implications in Huntington's disease
2014, Pharmacological ReportsCitation Excerpt :Caffeine, a methylxanthine, widely consumed for its central nervous system (CNS) stimulating properties, comes from dietary sources, mostly from coffee and tea. Acute/chronic intake of caffeine appears to have minor negative consequences and its absorption from the gastrointestinal tract is rapid and reaches 99% in humans/animals in about 45 min [12,13]. It is a well known fact that the striatum is robustly involved in the regulation of motor behaviour in animals and humans, and the ability of caffeine to stimulate motor behaviour and other neurological symptoms like psychosis, Parkinsonism and cerebral ischaemia are well documented [14–21].
The Janus face of caffeine
2013, Neurochemistry InternationalCitation Excerpt :These effects observed in the offspring’s exposed to caffeine could be partially explained by age-dependent metabolic differences. Caffeine is rapidly and completely absorbed by gastrointestinal tract and the excretion is predominantly renal (Arnaud 1976; Yesair et al. 1984). The absorption, bioavailability, and the urinary and fecal excretion of caffeine did not show differences between species (Arnaud, 1985; Arnaud et al., 1989; Walton et al., 2001).
High-performance liquid chromatographic method for simultaneous determination of [1-methyl-<sup>14</sup>C]caffeine and its eight major metabolites in rat urine
1999, Journal of Chromatography B: Biomedical Sciences and ApplicationsAre we dependent upon coffee and caffeine? A review on human and animal data
1999, Neuroscience and Biobehavioral ReviewsCaffeine demethylation measured by breath analysis in experimental liver injury in the rat
1995, Journal of Hepatology