Preliminary communicationObservations on the differential metabolism and biological activity of the optical isomers of cyclophosphamide
References (13)
- et al.
Biochem. Pharmac.
(1974) - et al.
Chem.-Biol. Interactions
(1972) - et al.
Clin.Chim.Acta
(1975) - et al.
Angew. Chem.
(1958) - P.J.COX, P.B.FARMER, A.B.FOSTER, E.D. GILBY and M.JARMAN, Cancer Chemother. Rep. in...
There are more references available in the full text version of this article.
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Biology of Human Cancer Unit, Ludwig Institute for Cancer Research at the Institute of Cancer Research.
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