Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle
References (17)
- et al.
Biochim. biophys. Acta
(1977) - et al.
Archs Biochem. Biophys.
(1978) - et al.
Biochem. Med.
(1974) - et al.
Biochem. biophys. Res. Commun.
(1977) - et al.
Biochim. biophys. Acta
(1976) - et al.
Nature (Lond.)
(1977) - et al.
Namyn-Schmiedeberg's Archs Pharmac.
(1979) - et al.
J. Pharmac. exp. Ther.
(1981)
Cited by (127)
Phosphodiesterase 1 inhibition and molecular docking study of phytochemicals isolated from stem heartwood of Heterophragma adenophyllum Seem
2020, South African Journal of BotanyCitation Excerpt :These intracellular signals were then relieving vasoconstriction and inflammation through interaction with other kinase enzymes. One of the famous PDE-I inhibitors is vinpocetine (Hagiwara et al., 1984) which is used as a vasodilator (Miyazaki, 1995). Our tested compounds significantly blocked the PDE-I and might be a potential vasodilator and anti-inflammatory.
Vinpocetine facilitates the anti-amnesic activity of estrogen-receptor alpha agonist in bilateral ovariectomy-challenged animals
2020, Behavioural Brain ResearchAn update on vinpocetine: New discoveries and clinical implications
2018, European Journal of PharmacologyA comprehensive review on the potential therapeutic benefits of phosphodiesterase inhibitors on cardiovascular diseases
2017, Biomedicine and PharmacotherapyCitation Excerpt :In vitro, PDE1A and PDE1B give the impression of having a high specificity for cGMP, whereas PDE1C has similar affinity for both cGMP and cAMP [38,39]. The foremost PDE1 inhibitors are nimodipine [40], vinpocetine [41], IC224 [42], phenothiazines, and SCH51866 [43]. Previously, researchers have realized the lack of information about the presence of PDEs in cardiac myocytes [44] and the nonattendance of specific inhibitors of PDE1 clarifies why there has been little examination of the impacts of PDE1 hindrance in models of CVD.