Binding of [3H]-p-aminoclonidine to α2adrenoceptor states plus a non-adrenergic site on human platelet plasma membranes
References (56)
- et al.
Evaluation of studies on platelet alpha2 adrenoceptors in depressive illness
Life Sci
(1986) - et al.
Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain
Life Sci
(1986) - et al.
Clonidine binds to imidazoline binding sites as well as α2-adrenoceptors in the ventrolateral medulla
Eur J Pharmacol
(1987) - et al.
High affinity binding of 3H rauwolscine and 3H RX781094 to α2 adrenergic receptors and non-stereoselective sites in human and rabbit brain cortex membranes
Biochem Pharmacol
(1989) - et al.
α2-Adrenoceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment
Brain Res
(1981) Antidepressant drugs and down-regulation of presynaptic receptors
Biochem Pharmacol
(1987)- et al.
Reversal of behavioral depression by infusion of an alpha-2 adrenergic agonist into the locus coeruleus
Neuropharmacology
(1986) - et al.
Increased 3H-clonidine binding in the platelets of patients with depressive and schizophrenic disorders
Psychiatry Res
(1989) - et al.
Platelet 3H-clonidine and 3H-imipramine binding and plasma Cortisol level in depression
Biol Psychiatry
(1989) - et al.
Large-scale purification of α2-adrenergic receptor-enriched membranes from human platelets. Persistent association of guanine nucleotides with nonpurified membranes
Biochim Biophys Acta
(1986)
The curvilinear Scatchard plot experimental artifact or receptor heterogeneity
Biochem Pharmacol
Ligand: A versatile computerized approach for characterization of ligand-binding systems
Anal Biochem
Clonidine displacing substance is biologically active on smooth muscle
Eur J Pharmacol
A low molecular weight brain substance interacts, similarly to clonidine, with α2-adrenoceptors of human platelets
Eur J Pharmacol
Critical assessment of the platelet adenylate cyclase system as a potential model for testing alpha2 adrenergic activity
Biochem Pharmacol
Temperature effects on α2-adrenergic receptor-G, interactions
Biochem Pharmacol
α2-Adrenergic receptors in human polymorphonuclear leukocyte membranes
Biochem Pharmacol
Cloning, sequencing, and expression of the gene coding for the human platelet α2-adrenergic receptor
Science
Characterization of alpha-adrenergic receptors in human platelets using [3H]clonidine
Mol Pharmacol
([3H]Clonidine binds at multiple high affinity states in human prefrontal cortex
Eur J Pharmacol
Platelet α2-adrenergic receptors in major depressive disorder. Binding of tritiated clonidine before and after tricyclic antidepressant drug treatment
Arch Gen Psychiatry
Platelet α2-adrenergic receptors in depression
Arch Gen Psychiatry
Alpha2-adrenoceptors in depression
Psychiatr Dev
Comparison of 3H-para-aminoclonidine binding to different platelet preparations
J Neural Transm
Altered platelet α2-adrenergic receptor binding sites in borderline personality disorder
Am J Psychiatry
3H-Clonidine and 3H-p-aminoclonidine interactions in vitro with central and peripheral α2-adrenergic receptors
Cloning and expression of a human kidney cDNA for an α2-adrenergic receptor subtype
Cloning of a new G-protein-coupled receptor homologous to the alpha-2 adrenergic receptor
Soc Neurosci Abstr
Cited by (62)
Identification and characterization of platelet α<inf>2</inf>- adrenoceptors and imidazoline receptors in rats, rabbits, cats, dogs, cattle, and horses
2013, European Journal of PharmacologyCitation Excerpt :Two imidazoline compounds also inhibit platelet adenylate cyclase through non-α2-adrenoceptor mechanisms (Ferry et al., 1986). Some studies have demonstrated nonadrenergic, imidazoline (I)-preferring binding sites (Il- and I2-receptors) in human platelets (Michel et al., 1990; Piletz et al., 1991; Piletz and Sletten, 1993; Zonnenschein et al., 1990). In dogs and cats, epinephrine alone does not induce platelet aggregation but can potentiate platelet aggregation stimulated by other platelet agonists (Hart and Nolte, 1991; Hikasa et al., 1999; Kitzen et al., 1991; Meyers et al., 1983; Tschopp, 1970).
Cardiovascular adjustments for life at high altitude
2007, Respiratory Physiology and NeurobiologyPsychiatric disorders
2007, PlateletsPsychiatric disorders
2006, Platelets, Second EditionImidazoline antihypertensive drugs: A critical review on their mechanism of action
2002, Pharmacology and TherapeuticsCitation Excerpt :However, in several other studies, a fairly high affinity for I1-binding sites was found (Bricca et al., 1989b; Hamilton et al., 1991; Piletz et al., 1996). UK14304 (not shown in Table 2) has high affinity for α2-adrenoceptors (Ki = 1–2 nM) (Piletz et al., 1991; Bricca et al., 1993). Its affinity for I1-binding sites was very low in the rabbit brain stem (Ki = 1531 nM) (Bricca et al., 1993), but high, comparable with its affinity for α2-adrenoceptors, in human platelets (Ki = 2 nM) (Piletz et al., 1991).
Enigmatic receptors
2000, Pharmaceutica Acta Helvetiae