Mechanism(s) regulating inhibition of thymidylate synthase and growth by γ-L-glutaminyl-4-hydroxy-3-iodobenzene, a novel melanin precursor, in melanogenic melanoma cells
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2017, South African Journal of BotanyCitation Excerpt :The high absorbance for intracellular melanin could be ascribed to the benzoquinones found in R. melanophloeos. Gamma-l-glutaminyl-3-4-benzoquinone is a precursor in the production of melanin, therefore, the absorbance reading could have included both the melanin produced and the γ-l-glutaminyl-3-4-benzoquinone present (Prezioso et al. 1993). Consequently, the absorbance gave a false positive; possibly because γ-l-glutaminyl-3-4-benzoquinone was mostly present, there was no mature melanin which could move to the extracellular space.
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