Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain
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2023, Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable-Case Studies for Critical ThinkingCytochrome P450 enzymes and metabolism of drugs and neurotoxins within the mammalian brain
2022, Advances in PharmacologyCitation Excerpt :These three CYP subfamilies are expressed in diverse cell types in the brain, including multiple neuronal subtypes, astrocytes and other glia, as well as endothelial cells (Booth Depaz et al., 2015; Ghosh et al., 2016; Miksys, Rao, et al., 2000; Norris et al., 1996). CYP2C, -2D, and -3A protein is localized in cell bodies and processes, and these have been detected in mitochondrial and plasma membrane fractions of neurons (Booth Depaz et al., 2015; Chinta et al., 2002; Ghersi-Egea et al., 1993; Neve & Ingelman-Sundberg, 2008). Some CYP genes are highly genetically variable, and genetic polymorphisms can alter gene expression and influence the amount or function of CYP protein produced (Ingelman-Sundberg, 2004; Ingelman-Sundberg, Oscarson, & McLellan, 1999; Preissner et al., 2013).
Pathophysiological implications of neurovascular P450 in brain disorders
2016, Drug Discovery TodayCitation Excerpt :The enzymes studied were CYP1B1, CYP2D6, CYP2E1, CYP2J2, CYP2U1, and CYP46A1, with pronounced heterogeneous distributions in different brain areas [9,22]. Expression of P450s in astrocytes has also been reported [5,6]. The latter is relevant to the notion of a metabolic barrier, because astrocytic end-feet envelop the cerebrovasculature.
First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo
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