Elsevier

Biochemical Pharmacology

Volume 48, Issue 7, 7 October 1994, Pages 1315-1318
Biochemical Pharmacology

Commentary
Control of the ductus arteriosus—A new function for cytochrome P450, Endothelin and nitric oxide

https://doi.org/10.1016/0006-2952(94)90552-5Get rights and content

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      The previous studies believe that this vasodilator role of PGE2, mainly via its E-prostanoid receptor 4 (EP4), one of a G-protein-coupled receptors (GPCRs), is to remodel DA in fetal. The duct functionally close shortly after birth caused from circulation PGE2 drop and systemic PO2 raise by constricted leading DA smooth muscle cells (DASMCs) [9]. O2 sensitivity of K+ channels have been described in various specialized O2-sensing tissues like chemoreceptors in the carotid body, pulmonary smooth muscle cells (SMCs), neuroepithelial bodies, placenta, and adrenal chromaffin cells [10].

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