Short communicationAge but not gender selectively affects expression of individual cytochrome P450 proteins in human liver
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2021, Frontiers in NeuroendocrinologyCitation Excerpt :In addition, the age-dependent change in the cytochrome P450 system has to be taken into account when considering ingested pharmaceuticals or chemicals. Here, age affects the total amount of the xenobiotic-degrading enzymes but also their composition (George et al., 1995). Interestingly, increased CYP27B1 expression has been specifically found in the duodenum of mice and humans during puberty (Gawlik et al., 2015) suggesting also its involvement in regulating the microbial gut commensals composition.
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