Research paperDistribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues
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2012, Journal of Clinical and Experimental HepatologyCitation Excerpt :Liver graft microsomes were used to study effects of treprostinil on the protein expression of the three major CYP450 enzymes, CYP3A2, CYP2C11, and CYP2E1, at 48 h post-OLT by Western immunoblotting. Rat CYP3A1 and CYP3A2 share 89% homology16 and treprostinil significantly improved CYP3A2 protein levels by 2.3-fold that of placebo (Figure 3A). The most notable effect of treprostinil occurred with CYP2E1, where treprostinil restored CYP2E1 protein expression to 100%, vs. 64% of normal in the placebo-treated group (Figure 3B).
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