Elsevier

Brain Research

Volume 96, Issue 1, 10 October 1975, Pages 138-141
Brain Research

‘Barrel rotation’ induced by somatostatin in the non-lesioned rat

https://doi.org/10.1016/0006-8993(75)90586-7Get rights and content

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Cited by (131)

  • Enzyme specificity and effects of gyroxin, a serine protease from the venom of the South American rattlesnake Crotalus durissus terrificus, on protease-activated receptors

    2014, Toxicon
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    The intravenous injection of this thrombin-like protease into mice triggers the barrel rotation syndrome, which is characterized by rotations of the animal around its long axis (Barrio, 1961). Although the suggestion of a putative intracerebral action of gyroxin involving neurotransmitters release (Cohn and Cohn, 1975), it was shown by others that gyroxin does not affect the release of dopamine and acetylcholine in vitro (Camillo et al., 2001). Several studies exploring different aspects of gyroxin features were reported in the recent years including: (1) the existence of gyroxin structural isoforms, demonstrated by the cloning of five different sequences from a cDNA library of C. d. terrificus venom glands (Yonamine et al., 2009); (2) the gyroxin ability to increase blood brain barrier (BBB) permeability (Alves da Silva et al., 2011); (3) the gyroxin action in central nervous system (CNS) suggested by its ability to modify the optical profiles of retinal spreading depression waves (RSDs) in chick retina (Da Silva et al., 2012); and (4) the gyroxin triggered activation of platelet aggregation, potentially mediated by protease-activated receptors (PARs) activation (Da Silva et al., 2012), suggested based on the thrombin mechanism of action that requires PARs to trigger the platelet aggregation (Coughlin, 1999; Kahn et al., 1998).

  • Gyroxin increases blood-brain barrier permeability to Evans blue dye in mice

    2011, Toxicon
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    This effect begins with a cataleptic stage followed by rolling movements similar to a barrel roll. This syndrome is associated with the intracerebral action of neuropeptides (Cohn and Cohn, 1975). Kruse et al. (1977) observed the same neurological effect after intracerebroventricular administration of arginine vasopressin in rats, and several studies were performed to better understand this pathological syndrome and also to define the location and mechanism involved in the genesis and development of the syndrome (Diamant et al., 1994; Kannan et al., 1994; Kawachi et al., 1998; Willcox et al., 1992; Wurpel et al., 1986a, b; Yoshizawa et al., 1990).

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This investigation was supported by NIMH Grant DA-00605.

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Linear somatostatin was generously supplied by Doctor Roger Guillemin of the Salk Institute, La Jolla, Calif.

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