Elsevier

Brain Research

Volume 348, Issue 2, 2 December 1985, Pages 355-358
Brain Research

Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons

https://doi.org/10.1016/0006-8993(85)90456-1Get rights and content

Abstract

Rats received unilateral injections of 6-hydroxydopamine into the medial forebrain bundle, resulting in an ipsilateral loss of striatal dopamine and of dopaminergic perikarya. A concimitant reduction of displaceable tritiated nicotine binding was observed autoradiographically in the ipsilateral substantia nigra, ventral tegmental area, striatum, nucleus accumbens, and olfactory tubercle. Thus, nicotine receptors appear to be located on nigrostriatal and mesolimbic dopaminergic neurons at the level of perikarya and terminals.

References (27)

Cited by (480)

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We thank Tim Sullivan for technical support, Mike Chiueh for HPLC instruction and Merrell Dow for gifts of desmethylimipramine. Paul Clarke is a Fogarty Visiting Fellow.

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