Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons
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2022, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Heterometric α4β2 and α7-containing receptors are the most abundant and widespread nicotinic receptors in the brain (Albuquerque et al., 2009). These nicotinic receptors have been identified in the cell bodies and/or dendrites within the VTA and terminal fields within the NAc in the mesolimbic dopamine system involved in reward and motivation (Nestler, 2001; Clarke and Pert, 1985; Deutch et al., 1987; Swanson et al., 1987). In the present study, we assessed food addiction-like behavior in a two-bottle sucrose preference test in mice, and examined the involvement of nicotinic receptors in food addiction-like behavior.
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2019, Neurobiology of DiseaseNicotine enhances responding for conditioned reinforcement via α4β2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex
2019, NeuropharmacologyCitation Excerpt :Lesions of this system or administration of DA receptor antagonists attenuate the locomotor stimulant effects of nicotine (Clarke et al., 1988) and nicotine self-administration (Corrigall and Coen, 1991; Corrigall et al., 1992). Nicotinic acetylcholine receptors (nAChRs) are found in DAergic neurons at the level of cell bodies in the VTA and terminal fields in the NAcc (Clarke and Pert, 1985; Clarke et al., 1984; Deutch et al., 1987; Swanson et al., 1987). Nicotine may then produce its reinforcement effects by acting on nAChRs in the VTA or the NAcc.
Nicotine protects against manganese and iron-induced toxicity in SH-SY5Y cells: Implication for Parkinson's disease
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2017, Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles
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We thank Tim Sullivan for technical support, Mike Chiueh for HPLC instruction and Merrell Dow for gifts of desmethylimipramine. Paul Clarke is a Fogarty Visiting Fellow.