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5.17 - The Thalamus and Nociceptive Processing
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionEnkephalinase regulation
2019, Vitamins and HormonesCitation Excerpt :If several neurotransmitters coexist in the same neuron, the alteration of one of them can affect the others and, as a consequence, the functions they exert. Considering enkephalins, these peptides have been described as coexisting, among others, with glutamate (Van Bockstaele, Saunders, Commons, Liu, & Peoples, 2000), gamma-aminobutyric acid (Van Bockstaele & Chan, 1997), serotonin (Tanaka, Okamura, Yanaihara, Tanaka, & Ibata, 1993), cholecystokinin (Gall, Lauterborn, Burks, & Seroogy, 1987) or catecholamines (Charnay et al., 1982). In relation to enkephalinases, Cicin-Sain, Simaga, Froebe, and Abramić (2008) studied enkephalinase activity in two sublines of rats, one with upregulated and the other with downregulated serotonin transporter activity.
Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain
2017, Biochemical and Biophysical Research CommunicationsCitation Excerpt :In the mammalian brain, CCK is one of the most abundant neuropeptides [5–7]. CCK's role in the brain is not completely clear, but there is compelling evidence to suggest that it is an essential component of processes underlying anxiety [8–11]; memory retention and learning [12], mood disorders such as depression [13–16] via the alteration of dopamine release [15,16], schizophrenia [17,18], and pain perception [19–23]. CCK is one of the neuropeptides in which the same primary translation product is processed into different molecular forms in different tissues.
Neurochemistry of Placebo Analgesia. Opioids, Cannabinoids and Cholecystokinin
2013, Placebo and Pain: From Bench to BedsideThe roles of nerve growth factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central nervous system inflammation
2009, NeuropharmacologyCitation Excerpt :Cholecystokinin (CCK) is implicated in a variety of physiological processes including cardiovascular and reproductive functions, feeding, sleep, learning and memory, anxiety, and nociception, particularly as an anti-opioid peptide (Crawley and Corwin, 1994; Cesselin, 1995; Fink et al., 1998). Anatomical evidence suggests a functional relationship between opioid peptides and CCK due to an overlap of these peptides in areas such as the periaqueductal gray matter, thalamus, and superficial lamina of spinal cord (Gall et al., 1987). Binding of the active sulfated form of CCK, CCK-8S, to the CCK receptors, mainly to the CCK-B receptor, reduces the binding affinity of morphine ligands (Wang et al., 1989; Wang and Han, 1990).
The Thalamus and Nociceptive Processing
2008, The Senses: A Comprehensive Reference
This work was supported by NSF Grant BNS 8417098 and Research Career Development Award NS00915 to C.G. K.B.S. was supported by PHS award MH09090.
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Present address: Department of Histology, Karolinska Institute, S-10401 Stockholm, Sweden.