Research reportStable depression of potentiated synaptic responses in the hippocampus with 1–5 Hz stimulation
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The role of dopamine D<inf>2</inf>-like receptors in a “depotentiation-like effect” of deep brain stimulation in kindled rats
2020, Brain ResearchCitation Excerpt :The “depotentiation-like effect” occurred concurrently with restoring the kindling-induced impairment in spatial learning and memory, in addition to the anticonvulsant action of LFS, which was shown in one of our previous studies (Esmaeilpour et al., 2017b). Many researchers have suggested that the anticonvulsant mechanisms of LFS may be similar to mechanisms involved in depotentiation (Fujii et al., 1991; Klausnitzer et al., 2004; Staubli and Lynch, 1990; Weiss et al., 1998) and/or LTD induction (Fujii et al., 2000; Manahan-Vaughan and Kulla, 2003; Toprani and Durand, 2013). Results of the present study provide evidence for the first time that a depotentiation-like effect occurs following LFS application in kindled animals, while no significant changes occur following LFS application in the control group.
Integrin Dynamics and Stages of Memory Formation
2017, Learning and Memory: A Comprehensive ReferenceLearning-Related Hippocampal Long-Term Potentiation and Long-Term Depression
2017, Learning and Memory: A Comprehensive ReferenceRegulation of Corticostriatal Synaptic Plasticity in Physiological and Pathological Conditions
2016, Handbook of Behavioral NeuroscienceLong-Term Potentiation and Long-Term Depression
2015, International Encyclopedia of the Social & Behavioral Sciences: Second EditionEffect of the initial synaptic state on the probability to induce long-term potentiation and depression
2015, Biophysical JournalCitation Excerpt :The results show, on average, 165% potentiation and 35% depression, in qualitative agreement with experimental findings (13,40). We also tested the ability of the model to erase LTP after its induction, an effect called depotentiation and experimentally found in CA1 neurons (41,42). To this purpose, all the synapses that were previously potentiated with the TBS LTP protocol received an additional 40-s conditioning period at a constant frequency of 1 Hz (42).