Spinal transection reduces both spinal antinociception and CNS concentration of systemically administered morphine in rats
Reference (26)
The role of descending inhibition in morphine-induced analgesia
Trends Pharmacol. Sci.
(1988)- et al.
Antinociceptive effect of systemic and intrathecal morphine in spinally transected rats
Eur. J. Pharmacol.
(1987) - et al.
Pharmacokinetics of a single dose of morphine in preterm infants during the first week of life
J. Pediatr.
(1990) - et al.
Quaternary naloxone blocks morphine analgesia in spinal but not intact rats
Neurosci. Lett.
(1990) - et al.
The blood spinal-cord barrier after injury: pattern of vascular events proximal and distal to a transection in the rat
Brain Research
(1987) - et al.
Extraction and measurement of morphine: correlation of brain level and s.c. dose in drug-naive and morphine-tolerant rats
Life Sci.
(1982) - et al.
Spinal vs supraspinal actions of morphine on the rat tail-flick reflex
Pain
(1988) - et al.
Antinociceptive effect of intrathecal morphine in tolerant and non-tolerant spinal rats
Pharmacol. Biochem. Behav.
(1989) - et al.
The synergistic effect of concurrent spinal and supraspinal opiate agonisms is reduced by both nociceptive and morphine pretreatment
Pharmacol. Biochem. Behav.
(1989) - et al.
Determination of morphine 3-glucuronide and (tentatively) morphine 6-glucoronide in plasma and urine using ion-pair high-performance liquid chromatography
J. Chromatogr.
(1982)
Influence of spinal cord transection on spinal cord blood flow in rats
Gen. Pharmacol.
Spinal analgesia: comparison of the μ agonist morphine and the κ agonist ethylketazocine
Life Sci.
Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry
Annu. Rev. Neurosci.
Cited by (42)
Transfer of Opiorphin Through a Blood-Brain Barrier Culture Model
2015, Archives of Medical ResearchCitation Excerpt :As a comparison, numerous endogenous peptides or regulatory proteins have <0.1%/g uptake in brain and are still effective in the CNS after peripheral administration (12–14,19). Among the opiates, the centrally active morphine has an uptake of only <0.02%/g brain (20). The amount of opiorphin transferred across the BBB culture model indicates that a specific transport mechanism, a peptide transport system or receptor-mediated transcytosis, may be involved in its transfer.
The glycine site-specific NMDA antagonist (+)-HA966 enhances the effect of morphine and reverses morphine tolerance via a spinal mechanism
2008, NeuropharmacologyCitation Excerpt :If so, such inhibitory processes are removed by the obex transection with a resultant unmasking of the effect of morphine. However, transection at spinal level was reported to significantly raise the concentration of morphine achieved in the central nervous system following an intravenous administration (Advokat and Gulati, 1991). We cannot exclude similar variations following a transection at the obex level.
Development of baclofen tolerance in a rat model of chronic spasticity and rigidity
2006, Neuroscience LettersBrain Influx of Endogenous Peptides Affecting Food Intake
2004, Blood-Spinal Cord and Brain Barriers in Health and Disease