Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor
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Keywords
Steroid
Allopregnanolone
Picrotoxin
Plus-maze
Anxiety
Sedation
Intracraial administration
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This work was supported by NIMH Grant MH 31850 and a Research Scientist Development Award (NIMH MH 00651) to C.K.K.
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The authors thank Dr. R. H. Purdy for the generous gift of allopregnanolone and pregnanolone.
Copyright © 1991 Published by Elsevier B.V.