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Naloxone-induced analgesia mediated by central kappa opioid system in chronic inflammatory pain
2021, Brain ResearchCitation Excerpt :However, the supraspinal KOR system contributes to the production of affective pain rather than analgesia (Knoll et al., 2007). The prototypical kappa opioid agonist, ethylketocyclazocine, only produce analgesia following co-administration into the periaqueductal gray and the locus coeruleus that was blocked by the mu1-selective antagonist, naloxonazine (Bodnar et al., 1991). The KOR system is also known to be facilitated within the limbic system in chronic pain, resulting in suppression of the morphine-induced rewarding effect in rats (Narita et al., 2005).
Opioid selective antinociception following microinjection into he periaqueductal gray of the rat
2014, Journal of PainCitation Excerpt :Microinjection of morphine, fentanyl, oxycodone, DAMGO, dermorphin, ß-endorphin, morphine-6ß-glucuronide, and [d-Ser2,Leu5]enkephalin-Thr6 into the PAG produces clear antinociceptive effects,5,7,27,42,50 whereas microinjection of methadone or buprenorphine has no effect. Likewise, antinociception does not occur following microinjection of the delta or kappa opioid receptor agonist deltorphin or ethylketocyclazocine into the PAG.6,32 These data demonstrate that even though opioids produce antinociception by binding to MOPrs, differences in MOPrs determine whether opioid binding is sufficient to produce antinociception.
Tolerance to morphine-induced antinociception is decreased by chronic sucrose or polycose intake
1999, Pharmacology Biochemistry and Behavior