Elsevier

Brain Research

Volume 571, Issue 2, 7 February 1992, Pages 272-280
Brain Research

Deoxycoformycin and oxypurinol: protection against focal ischemic brain injury in the rat

https://doi.org/10.1016/0006-8993(92)90665-VGet rights and content

Abstract

We have previously demonstrated that oxypurinol (40 mg/kg i.p.), a xanthine oxidase inhibitor, can reduce focal ischemic brain injury in the rat when applied pre-ischemically. By using a model of occlusion of the middle cerebral artery (MCA) in tandem with occlusion of the ipsilateral carotid artery, the present study further demonstrates that delayed (60 min) administration of oxypurinol also exhibits a protective action on ischemic damage in the stroked rat brain. Oxypurinol significantly reduced the ischemic cerebral infarct zone by preventing the development of brain damage primarily in areas distant to the central lesion core. A corresponding amelioration of brain swelling and attenuation of neurological deficits were evident. Similar protection against focal ischemic brain damage was evident when the adenosine deaminase inhibitor, deoxycoformycin (500 μg/kg), was administered prior to the onse of ischemia. However, with delayed (60 min) administration deoxycoformycin had no protective effect. These findings support the hypothesis that manipulation of adenosine catabolism can be an effective therapeutic approach to the prevention or treatment of brain injuries, such as those occuring during ischemic stroke or cardiac arrest.

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    • Cited by (0)

    This work was supported by NINDS R01 NS 26912-03 and the American Heart Association. The assistance of statistic analysis from Dr. Michael O'Regan is gratefully acknowledged.

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