Research reportCorticotropin-releasing factor induces a place aversion independent of its neuroendocrine role
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Central CRF and acute stress differentially modulate probabilistic reversal learning in male and female rats
2021, Behavioural Brain ResearchThe role of endogenous pituitary adenylyl cyclase activating polypeptide (PACAP) in nicotine self-administration, reward and aversion
2019, Pharmacology Biochemistry and BehaviorCitation Excerpt :Our results demonstrated that mice of both genotypes exhibited a comparable CPP, suggesting that the rewarding action of nicotine was not altered in the absence of PACAP. Considering that PACAP increases the expression of CRH (Agarwal et al., 2005; Grinevich et al., 1997; Stroth and Eiden, 2010; Stroth et al., 2011a; Stroth et al., 2011b), and that CRH induces conditioned place aversion (Cador et al., 1992) and taste aversion (Benoit et al., 2000), we then tested if the aversive effect of nicotine would be altered in the absence of PACAP. Our rationale was that nicotine consumption was enhanced in the absence of PACAP because the aversive effect of nicotine may have been reduced in the absence of PACAP.
Corticotropin-releasing factor in ventromedial prefrontal cortex mediates avoidance of a traumatic stress-paired context
2017, NeuropharmacologyCitation Excerpt :Brain CRF is dysregulated in psychiatric disorders including anxiety disorders, depression, and drug use disorders (George and Koob, 2010). Central administration of CRF increases anxiety-like behaviors and autonomic stress responses (Dunn and Berridge, 1990; Fisher, 1989), and produces conditioned place aversion (Cador et al., 1992). CRF1 receptors (CRFR1) mediate anxiety-like behavior and hyperarousal in stressed rats (Heinrichs and Koob, 2004; Roltsch et al., 2014).
The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction
2016, Progress in Molecular Biology and Translational ScienceSerotonergic versus nonserotonergic dorsal raphe projection neurons: Differential participation in reward circuitry
2014, Cell ReportsCitation Excerpt :However, the DRN is also noted to contain several peptidergic cell types, including corticotropin-releasing factor and substance P (Valentino and Commons, 2005). Although these peptides are aversive when administered intracerebroventricularly (Cador et al., 1992; Elliott, 1988), we cannot rule out the possibility that these or other DRN cell types contribute to reinforcement learning. With these caveats in mind, the most parsimonious interpretation of the data presented is that this population of nonserotonergic glutamate neurons is highly efficacious in driving reward-related behavior.