Research reportDopamine D1 receptors are involved in the modulation of D2 receptors induced by cholecystokinin receptor subtypes in rat neostriatal membranes
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2003, Life SciencesCitation Excerpt :Recent findings have provided evidence for CCK/DA receptor interactions in the CPu and NAc. Autoradiographic and biochemical binding studies indicate that CCK reduces the affinity of D2 receptors in the CPu and NAc (Li et al., 1994). It was demonstrated using in vitro filter wipe-off technique, that the reduction in affinity of the D2 agonist binding sites in the striatum by CCK is mediated via the activation of the CCK-2R subtype, since this effect was counteracted by the CCK-2R antagonist PD134308 (Ferraro et al., 1996).
The effect of isolation rearing on volitional ethanol consumption and central CCK/dopamine systems in Fawn-Hooded rats
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