Role of the N-terminal arginine in the histamine-releasing activity of substance P, bradykinin and related peptides
References (40)
New directions in asthma. Some cause for concern
Trends Pharmacol. Sci.
(1988)- et al.
Tools for tachykinin and neuropeptide research: a conference report
Neurosci. Lett.
(1988) - et al.
Histamine release from rat peritoneal mast cells by kinin antagonists
European J. Pharmacol.
(1988) - et al.
Peptides and histamine release from rat peritoneal mast cells
European J. Pharmacol.
(1985) - et al.
Selective agonists for substance P and neurokinin receptors
Neuropeptides
(1987) - et al.
Guanine nucleotide binding regulatory proteins: mediators of transmembrane signaling
Trends Pharmacol. Sci.
(1987) - et al.
Suppression of passive cutaneous anaphylaxis by pertussis toxin, an islet activating protein as a result of inhibition of histamine release from mast cells
Biochem. Pharmacol.
(1983) - et al.
Simultaneous inhibition of inositol phospholipid breakdown, arachidonic acid release and histamine secretion in mast cells by islet-activating protein , pertussis toxin
J. Biol. Chem.
(1985) - et al.
Substance P and neurokinins: physiological roles associated with receptor subtypes
Trends Pharmacol. Sci.
(1988) - et al.
The actions of kinin antagonists on B1 and B2 receptor systems
European J. Pharmacol.
(1986)
Receptors for substance P. III. Classification by competitive antagonists
European J. Pharmacol.
An automated continuous-flow system for the extraction and fluorometric analysis of histmanine
Anal. Biochem.
Refinements in the automated fluorometric histamine analysis system
J. Immunol. Meth.
Competitive antagonists of bradykinin
Peptides
Study of granule reapperance and histamine synthesis in rat mast cells maintained in short term cultures
Cell. Immunol.
Comparison of the histamine releasing activity of substance P on mast cells and basophils from different species and tissues
Int. Arch. Allergy Appl. Immunol.
Human skin mast cells: their dispersion, purification and secretory characterization
J. Immunol.
Histamine release and local responses of rat and human skin to substance P and other mammalian tachykinins
Pharmacology
Characterization of neurokinin receptors in various isolated organs by the use of selective agonists
Life Sci.
Development of selective agonists for substance P and neurokinin receptors
Cited by (84)
Neurogenic airway microvascular leakage induced by toluene inhalation in rats
2012, European Journal of PharmacologyCitation Excerpt :To further investigate the role of tachykinin release induced by toluene, we evaluated effects of a tachykinin NK1 receptor antagonist, CP-99,994 [(+)-(2s,3s)-3-(2-methoxybenzylamino)-2-phenylpiperidine] (McLean et al., 1993; Piedimonte et al., 1993), on airway microvascular leakage induced by toluene. Previous studies of isolated rat peritoneal mast cells (Devillier et al., 1989; Mazurek et al., 1981) have suggested that tachykinins such as substance P induce mast cell degranulation without binding to a specific tachykinin receptor. Rat lung mast cells release histamine in response to high doses of substance P in vitro (Ali et al., 1986).
Expression and proliferative effect of hemokinin-1 in human B-cells
2011, PeptidesCitation Excerpt :In addition to classical NK1 receptor activation, other pathways for tachykinins signaling in lymphocytes have been previously described, which may involve a receptor-independent pathway requiring relatively high peptide concentrations (μM) to be activated [22]. SP has been shown to induce histamine release in mast cells [12,13,49] and induce a rise in intracellular calcium concentration in human T lymphocytes [23], via a receptor-independent mechanism in link with its cationic amphiphilic structure. This signal transduction pathway bypasses classical receptor activation, and Mousli et al. have suggested that the cationic amphiphilic nature of SP was responsible for a direct interaction with negatively charged cell membrane, resulting in insertion of the peptide into the membrane, then acquiring a membrane-spanning conformation which enables interactions with proteins in the cytosolic compartment, G proteins for example [33].
Cryptide signaling: Amphiphilic peptide-induced exocytotic mechanisms in mast cells
2008, Biochemical and Biophysical Research CommunicationsRole of bradykinin in gastric vasodilation caused by hypertonic saline and acid back diffusion
2004, Regulatory Peptides