Evidence for two leukotriene receptor types in the guinea-pig isolated ileum
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Characterization of the cysteinyl leukotriene 2 receptor in novel expression sites of the gastrointestinal tract
2011, American Journal of PathologyCitation Excerpt :It is also plausible that the CysLT2R has different roles in the two GI neuronal subpopulations: DRG versus myenteric plexus. Previous studies have demonstrated that cysteinyl leukotrienes promote gut motility35 and pharmacological inhibition of the CysLT1R alleviates indomethacin-induced gastrointestinal hypermotility.36 However, although leukotrienes might evoke similar responses in two neuronal subpopulations within the same plexus, the effector response can be completely different depending on the type of neuron (Dogiel type I excitatory motor neuron versus type II interneurons) and the total number of neurons being stimulated.32
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2000, Biochemical and Biophysical Research Communications
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