Rapid communicationAnalgesia by direct antagonism of nociceptor sensitization involves the arginine-nitric oxide-cGMP pathway
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2020, Biochemical PharmacologyCitation Excerpt :The involvement of the NO pathway in the peripheral analgesic actions of other drugs and endogenous substances has also been extensively investigated. There is evidence that peripheral cannabinoids (a CB1-dependent effect), PPAR-γ agonists, xylazine, hormones such as estradiol and melatonin, bovine lactoferrin, choline (via alpha-7 nicotinic receptors), hydrogen sulfide releasing drugs, phosphodiesterase inhibitors, and pertussis toxin engage the NO-cGMP signaling to promote peripheral antinociception in various experimental models of inflammatory pain [81,83,137,138,149–158]. In addition, not only did these analgesic drugs and endogenous substances elicit peripheral analgesia through the activation of the NO pathway, but there was also compelling evidence that alternative therapies such as electroacupuncture and natural products (e.g., plant extracts, venoms, and toxins) also required the integrity of this pathway to exert peripheral analgesia [152,159–165].