Elsevier

European Journal of Pharmacology

Volume 242, Issue 2, 28 September 1993, Pages 195-198
European Journal of Pharmacology

Short communication
Serotonin-5-O-carboxymethyl-glycyl[125I]tyrosinamide labels the 5-HT1Dβ receptor subtype in human cortex

https://doi.org/10.1016/0014-2999(93)90080-2Get rights and content

Abstract

This study, carried out in human cerebral cortical membranes, confirms previous findings in human substantia nigra that serotonin-5-O-carboxymethyl-glycyl[125I]tyrosinamide ([125I]GTI) labels a homogenous population of recognition sites consistent with a 5-HT1D receptor pharmacology. In addition the results indicate that, under the assay conditions described, [125I]GTI specifically labels the 5-HT1Dβ recognition site since ketanserin and ritanserin display a low affinity consistent with their activities at this subtype of the 5-HT1D receptor.

References (12)

There are more references available in the full text version of this article.

Cited by (0)

View full text