The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia
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2021, Biochemical PharmacologyIfenprodil for prolonged spinal blockades of motor function and nociception in rats
2016, Pharmacological ReportsCitation Excerpt :In in vitro studies, ifenprodil interacts with serotonin (5-hydroxytryptamine; 5-HT) receptors [2] and sigma-1 or sigma-2 receptor [12–14]. As well as binding to those receptors, ifenprodil also blocks G protein-activated inwardly rectifying K+ channels [15], tetrodotoxin-resistant Na+ channels [16], voltage-gated Ca2+ channels [17–19], and Na+/Ca2+ exchanger in neurons [20]. Through blockade of voltage-gated Na+ channels, local anesthetics reversibly inhibit the conduction of electrical impulses in nerves [21,22].
Combination therapy of Ifenprodil with Piroxicam may be an effective therapeutic intervention in cerebral stroke: A hypothesis
2012, Medical HypothesesCitation Excerpt :Inhibition of NMDA receptor channels by ifenprodil is thought to have important implications in these therapeutic effects [34]. It has also been shown that ifenprodil interacts with several other receptors, namely, serotonin (5-hydroxytryptamine; 5-HT) subtype 1A, 5-HT2 and 5-HT3 receptors [18,35], and s receptors [36] at nanomolar concentrations and that it inhibits voltage-gated Ca2+ channels at micromolar concentrations [37,38]. These effects might also be involved in the molecular mechanisms underlying some of the therapeutic effects and side effects of ifenprodil.
Behavioral deficits and cellular damage following developmental ethanol exposure in rats are attenuated by CP-101,606, an NMDAR antagonist with unique NR2B specificity
2012, Pharmacology Biochemistry and BehaviorGlaucoma as a neuropathy amenable to neuroprotection and immune manipulation
2008, Progress in Brain ResearchCitation Excerpt :Another approach is to focus on the increased influx of calcium caused by the excess of glutamate and the hyperstimulation of voltage-gated calcium channels (Choi, 1988a, b). Indeed, some calcium channel blockers have been shown to reduce retinal damage (Takahashi et al., 1992; Bath et al., 1996). Neurotrophins are crucial for the normal maintenance of the CNS.