Research SectionThe pH of tobacco smokeLe pH de la fumée de tabacDer pH-Wert von Tabakrauch☆
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Cited by (103)
Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes
2021, Regulatory Toxicology and PharmacologyCitation Excerpt :The reduction of MTT leads to the formation of insoluble violet-blue formazan product, which are proportional to cell viability. Therefore, the acidic pH of the medium can modify the absorption spectrum of the cationic formazan altering the outcome of this test and representing an important bias for the interpretation of the results, particularly when it comes to tobacco products known to modify the pH of the medium (Brunnemann and Hoffmann, 1974; Henningfield et al., 1999). This aspect has to be considered when interpreting data from MTT assay on the effect of a complex chemical mixture, such as tobacco smoke and ENDS vapor, on cells, both to correctly interpret the result obtained and to evaluate a possible overestimation of viable cells.
History repeats itself: Role of characterizing flavors on nicotine use and abuse
2020, NeuropharmacologyCitation Excerpt :At the extremes of this range, the pH values of e-liquids are unprecedented. The pH of other tobacco product smokes only ranges from 5.5 to 7.5 (Benowitz et al., 2009; Brunnemann and Hoffmann, 1974). Therefore, more research is needed to understand how pharmacokinetics and nicotine bioavailability are affected at these extremes.
A comparison study on a sulfonated graphene-polyaniline nanocomposite coated fiber for analysis of nicotine in solid samples through the traditional and vacuum-assisted HS-SPME
2018, Journal of Pharmaceutical and Biomedical AnalysisA high area, porous and resistant platinized stainless steel fiber coated by nanostructured polypyrrole for direct HS-SPME of nicotine in biological samples prior to GC-FID quantification
2017, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesStandard addition method applied to the urinary quantification of nicotine in the presence of cotinine and anabasine using surface enhanced Raman spectroscopy and multivariate curve resolution
2013, Analytica Chimica ActaCitation Excerpt :A characteristic of our system that is noteworthy is the pH influence on the signal intensity. A qualitative comparison (results not included) of nicotine spectra at three different pH showed that peaks are more intense at pH below ≈6.0 where its protonated forms are present [38], condition fulfilled by mixing the sample with the colloid prior to spectral acquisition, taking into account the acid characteristics of the colloid (pH around 3.50) and the mixing ratio colloid:sample (10:1), that ensures the nicotine protonation. Despite being a minor tobacco alkaloid, anabasine was included in our experiments, since it is a biomarker used to monitor tobacco exposition during nicotine replacement therapy.
Effect of ammonia in cigarette tobacco on nicotine absorption in human smokers
2011, Food and Chemical ToxicologyCitation Excerpt :Most cigarettes sold in Europe and the US are made of flue-cured tobaccos, which are slightly acidic (pH 5.5–6.0). Under such acidic conditions nicotine is primarily present in its protonated form (Brunnemann and Hoffmann, 1974; Sensabaugh and Cundiff, 1967), whereas in alkaline milieu nicotine is present in its deprotonized form (free nicotine). In contrast to free nicotine, protonated (i.e. charged) nicotine poorly passes membranes and it is therefore believed to be less easily absorbed in the lungs (Pankow et al., 1997; Stevenson and Proctor, 2008; Wayne et al., 2006).
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No. XXV of “Chemical Studies on Tobacco Smoke”. Presented in part at the CORESTA/TCRC Meeting, Williamsburg, Va, 22–28 October 1972.