MinireviewThe physiological significance of heme oxygenase
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2019, Seminars in NephrologyCitation Excerpt :As a result, NO increases blood flow to tissues by decreasing vascular muscle tone. After being released into the plasma, Hb is cleared by hemoglobin and heme scavengers: haptoglobin and hemopexin, respectively.38,39 Once bound to haptoglobin, Hb is cleared by splenic and liver macrophages, and renal filtration and tubular injury can be prevented.40
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2014, Redox BiologyCitation Excerpt :Heme oxygenases (HO) represent a family of evolutionarily conserved endoplasmic reticulum (ER) enzymes that have been described as fonts of multiple messengers [1]. HO's are widely considered as the central components of mammalian stress response and defense against oxidative stress [2–5]. Three different isoforms of HO have been described in mammalian systems including the inducible HO-1; constitutive HO-2; and a newly identified HO-3, which is not catalytically active [6,7].
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