Research reportBiodistribution of clodronate and liposomes used in the liposome mediated macrophage ‘suicide’ approach☆
References (21)
- et al.
Serum-induced leakage of liposome contents
Biochim. Biophys. Acta
(1980) - et al.
In vivo distribution of particulate antigens and liposomes in murine spleen. A possible role in the immune response
Immunobiology
(1993) - et al.
The effect of elimination of macrophages on the tissue distribution of liposomes containing 3(H)methotraxate
Biochim. Biophys. Acta
(1984) - et al.
Liposome mediated affection of monocytes
Immunobiology
(1992) - et al.
Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes
Biochim. Biophys. Acta
(1994) - et al.
Amphiphatic poly(ethylene glycol) 5000-stabilized dioleoylphosphatidylethanolamine liposomes accumulate in spleen
Biochim. Biophys. Acta
(1992) - et al.
Efficient clodronate entrapment within multilamellar and unilamellar liposomes
J. Pharmacol. Toxicol.
(1992) - et al.
Disintegration of phosphatidyl-choline liposomes in plasma as a result of interaction with high-density lipoproteins
Biochim. Biophys. Acta
(1978) - et al.
Effects of liposome-encapsulated dichloromethylene diphosphonate on macrophage function and endotoxin-induced mortality
Biochim. Biophys. Acta
(1994) - et al.
An improved method of loading pH-sensitive liposomes with soluble proteins for class I restricted antigen presentation
J. Immunol. Methods
(1991)
Cited by (35)
Liposomes trigger bone marrow niche macrophage “foam” cell formation and affect hematopoiesis in mice
2022, Journal of Lipid ResearchLiposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine storm in COVID-19
2022, Medicine in Drug DiscoveryCitation Excerpt :It has been reported that intravenous administration of 20 mg of clodronate encapsulated with unilamellar liposomes significantly reduced macrophages and diminished inflammation in an experimental rat model of arthritis, while treatment of free clodronate had no effect in targeting macrophages [93,94]. The radioactive labelling-based animal experiments by Buiting have already demonstrated the in vivo distribution of clodronate in various organs including the liver and spleen [95]. Besides, the whole animal in vivo experiments described that the use of clodronate-liposome solution leads to efficient depletion of macrophages in the bone marrow, spleen, liver, lungs, brain, gut, peritoneal cavity, lymph nodes and in circulation thereby, suggesting liposome-encapsulated clodronate can spread to various organs in the body [96] (Figs. 2, 3, 4).
Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice
2017, Molecular Therapy Methods and Clinical DevelopmentCitation Excerpt :Liposomal clodronate pretreatment did not improve MΦ survival, though this may be due to residual liposomal clodronate killing transplanted MΦs. Liposomal clodronate injected intravenously (i.v.) is not detectable in the blood 3 hr post-injection,46 but administration i.p. may extend the overall clearance time. This may be addressed by a different injection schedule to allow for the clearance of liposomal clodronate before transplantation of MΦs.
Liposomal alendronate for the treatment of restenosis
2012, Journal of Controlled ReleaseCitation Excerpt :The mechanisms of cell death could play a role in tissues in which liposomes accumulate. In the vascular injury model (restenosis), since liposomal BPs deplete circulating monocytes which act as the transporters, they do not accumulate in the arterial wall [50, 58, 59, 92], but are disposed to some extent in other tissues (mainly the liver and spleen [50, 84, 87, 93]). Our results indicate that accumulation of LA in tissues does not induce side effects subsequent to cell necrosis.
- ☆
Correspondence to: T. Sminia, Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands. Fax: (31)204448081.
- 2
Present address: GI Cell Biology Laboratory, Children's Hospital, Harvard Medical School, Boston, MA, USA.