Elsevier

Life Sciences

Volume 3, Issue 6, June 1964, Pages 523-530
Life Sciences

Demonstration and mapping out of nigro-neostriatal dopamine neurons

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Abstract

In normal rats dopamine-storing nerve terminals are found in the neostriatum (= the caudate nucleus + putamen) and dopamine-containing nerve cells in the substantia nigra, mainly in the pars compacta. After electrolytic lesions in the substantia nigra or the internal capsule the histochemical fluorescence and the dopamine content of the neostriatum were markedly reduced. Removal of the neostriatum produced an increased fluorescence of the dopamine nerve cells of the substantia nigra and of their axons central to the lesion. These axons ascend as a nerve tract in the internal capsule towards the neostriatum. The data give strong evidence for the existence of nigro-neostriatal dopamine neurons, which probably contain most or all of the dopamine present in the neostriatum.

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