Elsevier

Life Sciences

Volume 13, Issue 12, 16 December 1973, Pages 1705-1713
Life Sciences

Induction of UDP glucuronyltransferase in the liver and extrahepatic organs of the rat

https://doi.org/10.1016/0024-3205(73)90117-3Get rights and content

Abstract

UDP glucuronyltransferase (4-methylumbelliferone) activity was enhanced in the liver of the rat after administering phenobarbital, cinchophen or 3-methylcholanthrene, in the lung after administration of cinchophen or 3-methylcholanthrene, and in the kidney after cinchophen. The UDP glucuronyltransferase of the spleen could not be induced with the dosage of the drugs used. Chlorpromazine was not able to induce either hepatic or extrahepatic UDP glucuronyltransferase. Chlorpromazine competitively inhibited hepatic UDP glucuronyltransferase in vitro.

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