Elsevier

Life Sciences

Volume 19, Issue 7, 1 October 1976, Pages 935-947
Life Sciences

Minireview
The role of humoral agents in volume expanded hypertension

https://doi.org/10.1016/0024-3205(76)90284-8Get rights and content

Abstract

It has long been known that increased salt intake or decreased salt excretion leads to elevated blood pressure and increased extracellular salt and volume. The blood pressure rises slowly and for this reason and others cannot be explained by the increased salt or volume per se. Rather it appears that pressure rises as a result of some indirect effect of the increased volume. Autoregulation has been implicated, but reasons are presented which make this an unlikely possibility. Recent evidence suggests that some humoral agent or agents, operating through the Na+−K+ pump in cardiovascular muscle, participate in the genesis of the volume expanded hypertensions.

References (119)

  • F.J. Haddy et al.

    Am. Heart J.

    (1973)
  • J.M. Ledingham et al.

    Lancet

    (1963)
  • D.Y. Solandt et al.

    Lancet

    (1940)
  • N.G. Levinsky

    Adv. Metab. Disord.

    (1974)
  • F.J. Haddy

    Cations and the Cardiovascular System

    (1973)
  • F.J. Haddy

    Arch. Intern. Med.

    (1974)
  • J. Mohring et al.

    Am. J. Physiol.

    (1975)
  • F.H.H. Leenen et al.

    Circ. Res.

    (1975)
  • E.D. Freis

    Circulation

    (1976)
  • J. Conway

    Circ. Res.

    (1966)
  • E.D. Frohlich

    Arch. Int. Pharmacodyn.

    (1966)
  • F.J. Haddy et al.

    Circ. Res.

    (1969)
  • T.E. Emerson et al.

    Am. J. Physiol.

    (1970)
  • P.C. Cannon et al.

    Circulation

    (1970)
  • R.A. Norman et al.

    Am. J. Physiol.

    (1975)
  • F.J. Haddy et al.
  • F.A. Finnerty et al.

    Circ. Res.

    (1970)
  • H.W. Overbeck

    Circ. Res.

    (1972)
  • G. Simon et al.

    Circ. Res.

    (1975)
  • E.W. Hawthorne et al.

    Circ. Res.

    (1974)
  • T. Nivatpumin et al.

    Am. J. Physiol.

    (1975)
  • J. Scheuer et al.
  • T.G. Coleman et al.

    Circ. Res.

    (1969)
  • A.W. Cowley et al.

    Circ. Res.

    (1975)
  • C.M. Ferrario et al.

    Circ. Res.

    (1970)
  • C.M. Ferrario

    Am. J. Physiol.

    (1974)
  • T.G. Coleman et al.

    Circulation

    (1970)
  • J.M. Ledingham et al.

    Can. Med. Assoc. J.

    (1964)
  • J.M. Ledingham et al.

    Circ. Res.

    (1967)
  • H.J. Granger et al.

    Circ. Res.

    (1969)
  • K. Sagawa et al.

    Circ. Res.

    (1975)
  • E.L. Bravo et al.

    Clin. Res.

    (1975)
  • G. Onesti et al.

    Circ. Res.

    (1975)
  • J.L. Cangiano et al.

    Arch. Int. Med.

    (1976)
  • F.M. Abboud
  • A.L. Mark et al.

    Circ. Res.

    (1975)
  • J.K. Vyden et al.

    Clin. Res.

    (1972)
  • P.M. Hutchins et al.

    Circ. Res.

    (1974)
  • Y. Lundgren

    Acta Physiol. Scand

    (1974)
  • P. Blaquier et al.

    Am. J. Physiol.

    (1960)
  • G. Schaechtelin et al.

    Am. J. Physiol.

    (1963)
  • L.K. Dahl et al.

    Circ. Res.

    (1969)
  • A.M. Michelakis et al.

    J. Clin. Endo. and Met.

    (1975)
  • H. Mizukoski et al.

    J. clin. Endocrin.

    (1972)
  • S. Koletsky et al.

    Am. J. Physiol.

    (1964)
  • S. Koletsky et al.

    Circ. Res.

    (1963)
  • L.T. Skeggs et al.

    Circ. Res.

    (1975)
  • F.J. Haddy et al.

    Circulation

    (1962)
  • R.E. Shade et al.
  • J.F. Laird et al.

    Circ. Res.

    (1974)
  • Cited by (383)

    • Ouabain, endogenous ouabain and ouabain-like factors: The Na<sup>+</sup> pump/ouabain receptor, its linkage to NCX, and its myriad functions

      2020, Cell Calcium
      Citation Excerpt :

      Even before the aforementioned genetic engineering and antibody studies were performed several investigators began searching for an endogenous ligand that had first been postulated in the 1950′s [32]. The search greatly broadened and intensified (see [53]) following suggestions that this ligand (a NKA inhibitor) might be involved in the pathogenesis of salt-dependent hypertension [31,54,55]. The search culminated in 1991 with the identification by mass spectrometry (MS) of ouabain (“endogenous ouabain” or EO) purified from human plasma [56–58].

    • Sodium, chloride, and potassium

      2020, Present Knowledge in Nutrition: Basic Nutrition and Metabolism
    • Synthesis of Cardiac Steroids and Their Role on Heart Failure and Cancer

      2018, Studies in Natural Products Chemistry
      Citation Excerpt :

      The first evidence for the existence of endogenous CSs in humans is found to be dated since the 1970s. It was based on the possible presence of a natriuretic hormone that is associated with hypertension [22,23]. Nowadays, the existence of endogenous CSs is incontestable.

    • Endogenous cardiotonic steroids in kidney failure: A review and an hypothesis

      2015, Advances in Chronic Kidney Disease
      Citation Excerpt :

      Here, we focus on two endogenous CTS implicated in the pathogenesis of CKD and propose a feed-forward mechanism including specific elements by which one or both CTS become elevated in the circulation, raise BP, and promote kidney and cardiac damage. Three endogenous CTS (eCTS) of relevance to ECFV balance and long-term BP control have been isolated and identified by analytical means in human plasma and/or urine.24,34-36 The identified eCTS are ouabain, marinobufagenin (MBG), and telocinobufagin.

    View all citing articles on Scopus
    View full text