Elsevier

Life Sciences

Volume 18, Issue 12, 15 June 1976, Pages 1349-1358
Life Sciences

Minireview
The nature of receptors regulating the formation of cyclic AMP in brain tissue

https://doi.org/10.1016/0024-3205(76)90350-7Get rights and content

Abstract

Extensive studies of the past seven years have provided fundamental information on the pharmacological properties of receptors controlling formation of cyclic AMP in brain slices and homogenates. Receptors for adenosine, α- and β-adrenergic agonists, dopamine, serotonin, H1- and H2-histaminergic agonists, and prostaglandins of the E series have been defined and evidence for a glutamate receptor has been presented. Extrapolation of such pharmacological data to studies with whole animals should provide important information as to the physiological significance of specific cyclic AMP-generating systems to the function of the intact brain.

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