Elsevier

Life Sciences

Volume 27, Issue 18, 3 November 1980, Pages 1673-1677
Life Sciences

Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man

https://doi.org/10.1016/0024-3205(80)90642-6Get rights and content

Abstract

Eight healthy volunteers with a broad range in their ability to hydroxylate debrisoquine, a metabolic reaction which is under polymorphic genetic control, were given single oral doses of nortriptyline and antipyrine. There was a close correlation between an individual's ability to hydroxylate debrisoquine and nortriptyline (measured as plasma clerance of the drug) (Spearman rs = 0.83; p = 0.01). This indicates that these two benzylic hydroxylations are controlled by similar if not identical genetic factors. In contrast to nortriptyline the clearance of antipyrine (assessed in saliva) was not positively related to the ability to hydroxylate debrisoquine.

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    Present address: Department of Angiology and Geriatrics, Medical School of Lübeck, Federal Republic of Germany

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