Elsevier

Life Sciences

Volume 29, Issue 13, 28 September 1981, Pages 1325-1332
Life Sciences

Contractile activities of leukotrienes C4 and D4 on vascular strips from rabbits

https://doi.org/10.1016/0024-3205(81)90675-5Get rights and content

Abstract

Leukotrienes C4 (LTC4) and D4 (LTD4), major components of slow-reacting substances of anaphylaxis (SRS-A), caused dose-dependent contractions of rabbit coronary arteries in concentrations of 10−9 to 10−7 M and 10−10 to 10−7 M, respectively. The potency of LTC4 and LTD4, when compared with the concentration that elicits half of the contraction induced by 25 mM KCl, was 17 and 76 times, respectively, greater than that of histamine. In contrast, other blood vessels from rabbits were either unresponsive (renal artery and vein, mesenteric artery and thoracic aorta) or only weakly responsive (pulmonary artery and vein and portal vein) to both leukotrienes even at 10−7 M. The LTD4-induced coronary contraction was inhibited by FPL 55712 (10−7 and 10−6 M), a selective SRS-A inhibitor, in a dose-dependent manner, but not by diphenhydramine (10−7 M), a histamine H1-receptor blocker or by indomethacin (10−5 M), a prostaglandin synthetase inhibitor, suggesting that LTD4 has a direct effect on the coronary arteries. These results indicate that the leukotrienes may act as potent, selective coronary vasoconstrictors and that SRS-A responsive receptors exist in the rabbit coronary artery.

References (20)

  • G. Holme et al.

    Prostaglandins

    (1980)
  • N. Cohen et al.

    Tetrahedron Letters

    (1980)
  • J.G. Gleason et al.

    Tetrahedron Letters

    (1980)
  • H. Karaki et al.

    European J. Pharmacol.

    (1978)
  • T. Simmet et al.

    European J. Pharmacol.

    (1980)
  • H. Anhut et al.

    European J. Pharmacol.

    (1977)
  • L. Örnig et al.
  • R.A. Lewis et al.
  • B. Samuelsson et al.

    Allergy

    (1980)
  • P. Hedqvist et al.

    Acta Physiol. Scand.

    (1980)
There are more references available in the full text version of this article.

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