Elsevier

Life Sciences

Volume 39, Issue 23, 8 December 1986, Pages 2153-2159
Life Sciences

Minireview
Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1

https://doi.org/10.1016/0024-3205(86)90391-7Get rights and content

Abstract

Evidence is presented that the small peptides MIF-1/Tyr-MIF-1 are part of an endogenous antiopiate system that may function to balance the opiate system. We review the biological activity, behavioral activity, and functional effects of this proposed opiate antagonist system. In addition, we suggest, based on antinociceptive mechanisms, that the individual components of the antiopiate system might function differently from naloxone.

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