Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: Supra- and sub-additivity
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2015, Bioorganic and Medicinal Chemistry LettersN-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile
2013, Bioorganic and Medicinal Chemistry LettersCo-administration of δ- And μ-opioid receptor agonists promotes peripheral opioid receptor function
2010, PainCitation Excerpt :For example, the α2-adrenergic receptor agonist clonidine enhances post-operative morphine analgesia without augmenting side effects [8]. Previous results from animal studies have indicated that δ- and μ-opioid receptor interactions also have important functional consequences in the central nervous system (CNS), including synergistic analgesic outcomes [1,13,18,19,24,42]. However, much less is known about how these receptors interact in the periphery.
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2010, Journal of PainCitation Excerpt :In contrast, testing may reveal that a dose pair plots as a point above the isobole in attaining the specified effect E∗; this means a subadditive interaction (Fig 2). Numerous preclinical studies of analgesic combinations have employed the isobolographic approach.6,7,11,13,15,23,30,35,44,45,60 An especially interesting case is that in which 1 of the 2 drugs lacks efficacy.
Modulation Between High- and Low-Frequency Transcutaneous Electric Nerve Stimulation Delays the Development of Analgesic Tolerance in Arthritic Rats
2008, Archives of Physical Medicine and RehabilitationCitation Excerpt :Vaught and Takemori44 observed that Leu 5-enkephalin given at subantinociceptive doses potentiates the analgesic actions of the μ-opioid ligand morphine. Several other studies extended these observations to synergistic antinociceptive effects between other μ-opioid agonists and δ-opioid agonists.45,46 The activation of δ-opioid receptors has synergistic effects on μ-opioid functional activities in cells transfected with μ- and δ-opioid receptors.38,47,48