Intranigral injection of capsaicin enhances motor activity and depletes nigral 5-hydroxytryptamine but not substance P☆
References (26)
- et al.
Substance P release from spinal cord slices by capsaicin
Life Sci.
(1979) - et al.
Projections of substance P containing neurons from neostriatum to substantia nigra
Brain Res.
(1977) - et al.
Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system
Neuroscience
(1978) - et al.
Capsaicin-induced depletion of substance P from primary sensory neurons
Brain Res.
(1978) - et al.
Evidence for the existence of substance P-containing fibres in striato-nigral and pallido-nigral pathways in rat brain
Brain Res.
(1977) - et al.
Behavioural response to bilateral injections of substance P into the substantia nigra of the rat
Brain Res.
(1978) - et al.
Distribution of substance P-like immunoreactivity in the central nervous system of the rat—II. Light microscopic localization in relation to catecholamine-containing neurons
Neuroscience
(1978) - et al.
Evidence for substance P in the striato-nigral tract
Brain Res.
(1977) - et al.
Neurotoxic action of capsaicin on spinal substance P neurons
Brain Res.
(1980) - et al.
Regional rat brain levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid: concurrent fluorimetric measurement and influence of drugs
Eur. J. Pharmac.
(1976)
Dimethyl sulfoxide in experimental brain injury with comparison to mannitol
J. Neurosurg.
Regional distribution of substance P in the brain of the rat
Brain Res.
A study of the sites of interaction between dopamine and 5-hydroxytryptamine for the production of fluphenazine-induced catalepsy
Naunyn-Schmiedebergs Arch. Pharmac.
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Parkinson's disease related alterations in cannabinoid transmission
2022, Brain Research BulletinCitation Excerpt :The presence of TRPV1R and its agonist in the BG allow a direct action of these ECB/endovanilloid compounds on the excitability of nigrostriatal DAergic neurons (Marinelli et al., 2003). Stimulation of TRPV1R in the striatum also increased the frequency of glutamate-mediated spontaneous and miniature postsynaptic currents (sEPSCs and mEPSCs, respectively) (Musella et al., 2009), and heightened motor behavior (Dawbarn et al., 1981; Hajos et al., 1988). These receptors are co-expressed with CB1Rs in the striatum and GP (Cristino et al., 2006; Tóth et al., 2005), and functional interactions between these receptors have been reported in vitro (Hermann et al., 2003), and in vivo (Kim et al., 2005).
The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation
2010, Pharmacology and Therapeutics[<sup>3</sup>H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution
2004, Brain ResearchCitation Excerpt :The same tools have been used to explore the potential function of vanilloid receptors in the brain. Microinjection of capsaicin and RTX into various brain regions has evoked responses [6,15] but clear description of effects at the cellular level has only been achieved in limited cases. Perhaps the best characterised response is that in the locus coeruleus, where capsaicin application evokes glutamate release [10,12].
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia
2003, Journal of Biological ChemistryCitation Excerpt :Although the subject of VR1 receptors in brain has been controversial, mounting evidence indicates that VR1 receptors are, in fact, produced by the brain and are functional (26, 27) (see Refs. 25and 28 for reviews). Several putative central nervous system-mediated actions of VR1 receptors have been postulated, including modulation of motor function, body temperature, and pain (29-33). Notably, Palazzoet al. (33) found that microinjections of capsaicin into the periaqueductal gray matter caused analgesia to the same type of thermal stimulus used here, an effect opposite to that observed following intradermal injections.
Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues
2001, European Journal of Pharmacology
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A preliminary account of this work was presented to the British Pharmacological Society in Aberdeen, September 1980