Elsevier

Neuropharmacology

Volume 34, Issue 1, January 1995, Pages 1-26
Neuropharmacology

Review: Neurotransmitter receptors I
The metabotropic glutamate receptors: Structure and functions

https://doi.org/10.1016/0028-3908(94)00129-GGet rights and content

Abstract

Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels—termed NMDA, AMPA and kainate receptors—involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses.

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    This is the first in a regular series of review articles on neurotransmitter receptors with a special emphasis on their pharmacology and molecular biology.

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