Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA (‘Ecstasy’) to rats
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Cited by (77)
Current preclinical studies on neuroinflammation and changes in blood-brain barrier integrity by MDMA and methamphetamine
2014, NeuropharmacologyCitation Excerpt :There is a substantial body of evidence that glutamate antagonists are neuroprotective (Colado and Green, 1994), although the protection may primarily result from the drugs lowering body temperature (Colado et al., 1998). The GABAmimetic clomethiazole protects against MDMA-induced neurotoxicity (Colado and Green, 1994; Hewitt and Green, 1994) as does the nNOS inhibitor AR-R17477AR (Sanchez et al., 2003). The free radical trapping agent PBN protects against MDMA-induced damage (Colado and Green, 1995) and further experiments demonstrated that this was due to radical trapping in the brain (Colado et al., 1997).
Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats
2011, Brain ResearchCitation Excerpt :Another reason for concern is the long-lasting, possibly neurotoxic consequences of MDMA for the serotonergic system. Several preclinical studies have demonstrated that MDMA evokes a persistent decrease in serotonin and 5-hydroxyindoleacetic acid (5-HIAA), a reduction in tryptophan hydroxylase (TPH) activity, a reduction of serotonin transporter (SERT) activity and expression and finally a long-term impairment of anterograde transport in serotonin axons (Battaglia et al., 1987; Buchert et al., 2004; Callahan et al., 2001; Colado et al., 1993; Hewitt and Green, 1994; Ricaurte et al., 2000; Schmidt and Taylor, 1987; Semple et al., 1999; Sharkey et al., 1991; Stone et al., 1986; Xie et al., 2006). Although clinical studies on this matter are less conclusive, there is increasing evidence that MDMA can be toxic for the human brain too. (de Win et al., 2004; Grob, 2002; McCann et al., 2000; Turner and Parrott, 2000).
Long-term neurobiological consequences of ecstasy: A role for pre-existing trait-like differences in brain monoaminergic functioning?
2009, Pharmacology Biochemistry and BehaviorMDMA-induced serotonergic neurotoxicity enhances aggressiveness in low- but not high-aggressive rats
2009, European Journal of Pharmacology