Zolpidem functionally discriminates subtypes of native GABAA receptors in acutely dissociated rat striatal and cerebellar neurons
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2022, Bioorganic ChemistryCitation Excerpt :These parameters of Zolpidem effects are similar to those observed by Itier et. al (1996) [59] in the same preparation for GABA (1 µM)-evoked currents (EC50 is 33 nM and the maximal potentiation is 189%). In the presence of Flumazenil, a certain effect of hybrid molecule 15e was still present although it developed much slower than in the absence of the BZD site blocker, indicating that compound 15e interacts also with another site of the GABAA receptor.
Development of 1,3-thiazole analogues of imidazopyridines as potent positive allosteric modulators of GABA<inf>A</inf> receptors
2020, Bioorganic ChemistryCitation Excerpt :The functional properties of GABAARs from Purkinje cells also suggest the presence of α1, β2, β3, and γ2 subunits. These include high sensitivity to ZLP [55,56], indicating the presence of the α1 subunit. The type of the receptor expressed in Purkinje cells is the most common type of GABAARs in the brain with the subunit composition α1β2γ2 [5].
The mechanisms of potentiation and inhibition of GABA<inf>A</inf> receptors by non-steroidal anti-inflammatory drugs, mefenamic and niflumic acids
2019, NeuropharmacologyCitation Excerpt :The functional properties of GABAARs from Purkinje cells also suggest the presence of α1, β2, β3, and γ2 subunits. These include high sensitivity to zolpidem (Itier et al., 1996) indicating the presence of the α1 subunit. Our data on the high sensitivity of GABA-induced currents to ETM and MFA indicate the presence of the β2, β3 subunits in Purkinje cells.
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